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SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice

The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled testing of vaccines and therapeutics and defining aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. SARS-CoV-2 disease is severe in K18 transgenic mice (K18-hACE2 Tg) expressing hu...

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Detalles Bibliográficos
Autores principales:	Winkler, Emma S., Chen, Rita E., Alam, Fahmida, Yildiz, Soner, Case, James Brett, Uccellini, Melissa B., Holtzman, Michael J., Garcia-Sastre, Adolfo, Schotsaert, Michael, Diamond, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754206/ https://www.ncbi.nlm.nih.gov/pubmed/34668780 http://dx.doi.org/10.1128/JVI.01511-21

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