Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity

AIM: To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS: Analysis included the REQ...

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Detalles Bibliográficos
Autores principales: Franco, Nicola Rares, Massi, Michela Carlotta, Ieva, Francesca, Manzoni, Andrea, Paganoni, Anna Maria, Zunino, Paolo, Veldeman, Liv, Ost, Piet, Fonteyne, Valérie, Talbot, Christopher J., Rattay, Tim, Webb, Adam, Johnson, Kerstie, Lambrecht, Maarten, Haustermans, Karin, De Meerleer, Gert, de Ruysscher, Dirk, Vanneste, Ben, Van Limbergen, Evert, Choudhury, Ananya, Elliott, Rebecca M., Sperk, Elena, Veldwijk, Marlon R., Herskind, Carsten, Avuzzi, Barbara, Noris Chiorda, Barbara, Valdagni, Riccardo, Azria, David, Farcy-Jacquet, Marie-Pierre, Brengues, Muriel, Rosenstein, Barry S., Stock, Richard G., Vega, Ana, Aguado-Barrera, Miguel E., Sosa-Fajardo, Paloma, Dunning, Alison M., Fachal, Laura, Kerns, Sarah L., Payne, Debbie, Chang-Claude, Jenny, Seibold, Petra, West, Catharine M.L., Rancati, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754257/
https://www.ncbi.nlm.nih.gov/pubmed/33838170
http://dx.doi.org/10.1016/j.radonc.2021.03.024

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