Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity

Preclinical studies of primary cancer cells are typically done after tumors are removed from patients or animals at ambient atmospheric oxygen (O(2), ~21%). However, O(2) concentrations in organs are in the ~3 to 10% range, with most tumors in a hypoxic or 1 to 2% O(2) environment in vivo. Although...

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Detalles Bibliográficos
Autores principales: Kumar, Brijesh, Adebayo, Adedeji K., Prasad, Mayuri, Capitano, Maegan L., Wang, Ruizhong, Bhat-Nakshatri, Poornima, Anjanappa, Manjushree, Simpson, Edward, Chen, Duojiao, Liu, Yunlong, Schilder, Jeanne M., Colter, Austyn B., Maguire, Callista, Temm, Constance J., Sandusky, George, Doud, Emma H., Wijeratne, Aruna B., Mosley, Amber L., Broxmeyer, Hal E., Nakshatri, Harikrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754301/
https://www.ncbi.nlm.nih.gov/pubmed/35020422
http://dx.doi.org/10.1126/sciadv.abh3375

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