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Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD(+) biosynthesis and sustain cardiac function

The heart is a highly metabolic organ that uses multiple energy sources to meet its demand for ATP production. Diurnal feeding-fasting cycles result in substrate availability fluctuations which, together with increased energetic demand during the active period, impose a need for rhythmic cardiac met...

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Detalles Bibliográficos
Autores principales:	Dierickx, Pieterjan, Zhu, Kun, Carpenter, Bryce J., Jiang, Chunjie, Vermunt, Marit W., Xiao, Yang, Luongo, Timothy S., Yamamoto, Tsunehisa, Martí-Pàmies, Íngrid, Mia, Sobuj, Latimer, Mary, Diwan, Abhinav, Zhao, Juanjuan, Hauck, Amy K., Krusen, Brianna, Nguyen, Hoang C.B., Blobel, Gerd A., Kelly, Daniel P., Pei, Liming, Baur, Joseph A., Young, Martin E., Lazar, Mitchell A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754391/ https://www.ncbi.nlm.nih.gov/pubmed/35036997 http://dx.doi.org/10.1038/s44161-021-00001-9

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