De novo mutations identified by whole-genome sequencing implicate chromatin modifications in obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder with a substantial genetic basis and a broadly undiscovered etiology. Recent studies of de novo mutation (DNM) exome-sequencing studies for OCD have reinforced the hypothesis that rare variation contributes to the risk. We performed,...

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Detalles Bibliográficos
Autores principales: Lin, Guan Ning, Song, Weichen, Wang, Weidi, Wang, Pei, Yu, Huan, Cai, Wenxiang, Jiang, Xue, Huang, Wu, Qian, Wei, Chen, Yucan, Chen, Miao, Yu, Shunying, Xu, Tingting, Jiao, Yumei, Liu, Qiang, Zhang, Chen, Yi, Zhenghui, Fan, Qing, Chen, Jue, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754407/
https://www.ncbi.nlm.nih.gov/pubmed/35020433
http://dx.doi.org/10.1126/sciadv.abi6180

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