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Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission

The engineered protein eCD4Ig has emerged as a promising approach to achieve HIV remission in the absence of antiviral therapy. eCD4Ig neutralizes nearly all HIV-1 isolates and induces antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro. To characterize the in vivo antiviral neutralization...

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Detalles Bibliográficos
Autores principales:	Goyal, Ashish, Gardner, Matthew, Mayer, Bryan T., Jerome, Keith R., Farzan, Michael, Schiffer, Joshua T., Cardozo-Ojeda, E. Fabian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754410/ https://www.ncbi.nlm.nih.gov/pubmed/35020436 http://dx.doi.org/10.1126/sciadv.abj5666

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