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Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study
BACKGROUND: This study aims to add to the body of evidence linking obesity as an established risk factor for COVID-19 infection and also look at predictors of mortality for COVID-19 in the African-Americans (AA) population. METHODS: A retrospective cohort study of patients with confirmed COVID-19 in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754527/ https://www.ncbi.nlm.nih.gov/pubmed/35023056 http://dx.doi.org/10.1007/s40615-021-01206-1 |
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author | Garlapati, Pavani Reddy Kumar, Suneet Patel, Meet Sarker, Bidyut Tiongson, Benjamin Adapa, Sreedhar Salim, Sohail Abdul Adler, Mark K. Gayam, Vijay Reddy |
author_facet | Garlapati, Pavani Reddy Kumar, Suneet Patel, Meet Sarker, Bidyut Tiongson, Benjamin Adapa, Sreedhar Salim, Sohail Abdul Adler, Mark K. Gayam, Vijay Reddy |
author_sort | Garlapati, Pavani Reddy |
collection | PubMed |
description | BACKGROUND: This study aims to add to the body of evidence linking obesity as an established risk factor for COVID-19 infection and also look at predictors of mortality for COVID-19 in the African-Americans (AA) population. METHODS: A retrospective cohort study of patients with confirmed COVID-19 infection was done in a community hospital in New York City. The cohort was divided into two groups, with the non-obese group having a BMI < 30 kg/m(2) and the obese group with a BMI ≥ 30 kg/m(2). Clinical predictors of mortality were assessed using multivariate regression analysis. RESULTS: Among the 469 (AA) patients included in the study, 56.3% (n = 264) had a BMI < 30 kg/m(2) and 43.7% (n = 205) had a BMI ≥ 30 kg/m(2). Most common comorbidities were hypertension (n = 304, 64.8%), diabetes (n = 200, 42.6%), and dyslipidemia (n = 74, 15.8%). Cough, fever/chills, and shortness of breath had a higher percentage of occurring in the obese group (67.8 vs. 55.7%, p = 0.008; 58.0 vs. 46.2%, p = 0.011; 72.2 vs. 59.8%, p = 0.005, respectively). In-hospital mortality (41.5 vs. 25.4%, p < 0.001) and mechanical ventilation rates (34.6 vs. 22.7%, p = 0.004) were also greater for the obese group. Advanced age (p = 0.034), elevated sodium levels (p = 0.04), and elevated levels of AST (0.012) were associated with an increase in likelihood of in-hospital mortality in obese group. CONCLUSIONS: Our results show that having a BMI that is ≥ 30 kg/m(2) is a significant risk factor in COVID-19 morbidity and mortality. These results highlight the need for caution when managing obese individuals. |
format | Online Article Text |
id | pubmed-8754527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-87545272022-01-13 Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study Garlapati, Pavani Reddy Kumar, Suneet Patel, Meet Sarker, Bidyut Tiongson, Benjamin Adapa, Sreedhar Salim, Sohail Abdul Adler, Mark K. Gayam, Vijay Reddy J Racial Ethn Health Disparities Article BACKGROUND: This study aims to add to the body of evidence linking obesity as an established risk factor for COVID-19 infection and also look at predictors of mortality for COVID-19 in the African-Americans (AA) population. METHODS: A retrospective cohort study of patients with confirmed COVID-19 infection was done in a community hospital in New York City. The cohort was divided into two groups, with the non-obese group having a BMI < 30 kg/m(2) and the obese group with a BMI ≥ 30 kg/m(2). Clinical predictors of mortality were assessed using multivariate regression analysis. RESULTS: Among the 469 (AA) patients included in the study, 56.3% (n = 264) had a BMI < 30 kg/m(2) and 43.7% (n = 205) had a BMI ≥ 30 kg/m(2). Most common comorbidities were hypertension (n = 304, 64.8%), diabetes (n = 200, 42.6%), and dyslipidemia (n = 74, 15.8%). Cough, fever/chills, and shortness of breath had a higher percentage of occurring in the obese group (67.8 vs. 55.7%, p = 0.008; 58.0 vs. 46.2%, p = 0.011; 72.2 vs. 59.8%, p = 0.005, respectively). In-hospital mortality (41.5 vs. 25.4%, p < 0.001) and mechanical ventilation rates (34.6 vs. 22.7%, p = 0.004) were also greater for the obese group. Advanced age (p = 0.034), elevated sodium levels (p = 0.04), and elevated levels of AST (0.012) were associated with an increase in likelihood of in-hospital mortality in obese group. CONCLUSIONS: Our results show that having a BMI that is ≥ 30 kg/m(2) is a significant risk factor in COVID-19 morbidity and mortality. These results highlight the need for caution when managing obese individuals. Springer International Publishing 2022-01-13 2023 /pmc/articles/PMC8754527/ /pubmed/35023056 http://dx.doi.org/10.1007/s40615-021-01206-1 Text en © W. Montague Cobb-NMA Health Institute 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Garlapati, Pavani Reddy Kumar, Suneet Patel, Meet Sarker, Bidyut Tiongson, Benjamin Adapa, Sreedhar Salim, Sohail Abdul Adler, Mark K. Gayam, Vijay Reddy Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title | Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title_full | Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title_fullStr | Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title_full_unstemmed | Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title_short | Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19: a Single-Center Retrospective Study |
title_sort | clinical characteristics and predictors of mortality in obese african-americans with covid-19: a single-center retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754527/ https://www.ncbi.nlm.nih.gov/pubmed/35023056 http://dx.doi.org/10.1007/s40615-021-01206-1 |
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