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A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors

Clinical usage of lentiviral vectors is now established and increasing but remains constrained by vector titer with RNA packaging being a limiting factor. Lentiviral vector RNA is packaged through specific recognition of the packaging signal on the RNA by the viral structural protein Gag. We investi...

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Detalles Bibliográficos
Autores principales:	Vamva, Eirini, Griffiths, Alex, Vink, Conrad A, Lever, Andrew M L, Kenyon, Julia C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754630/ https://www.ncbi.nlm.nih.gov/pubmed/34928383 http://dx.doi.org/10.1093/nar/gkab1206

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