Mutation and selection explain why many eukaryotic centromeric DNA sequences are often A + T rich

We have used chromosome engineering to replace native centromeric DNA with different test sequences at native centromeres in two different strains of the fission yeast Schizosaccharomyces pombe and have discovered that A + T rich DNA, whether synthetic or of bacterial origin, will function as a cent...

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Detalles Bibliográficos
Autores principales: Barbosa, Anne C, Xu, Zhengyao, Karari, Kazhal, Williams, Wendi, Hauf, Silke, Brown, William R A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754631/
https://www.ncbi.nlm.nih.gov/pubmed/34928384
http://dx.doi.org/10.1093/nar/gkab1219

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