Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2 a...

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Detalles Bibliográficos
Autores principales: Ambike, Shubhankar, Cheng, Cho-Chin, Feuerherd, Martin, Velkov, Stoyan, Baldassi, Domizia, Afridi, Suliman Qadir, Porras-Gonzalez, Diana, Wei, Xin, Hagen, Philipp, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Grass, Vincent, Burgstaller, Gerald, Pichlmair, Andreas, Merkel, Olivia M, Ko, Chunkyu, Michler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754636/
https://www.ncbi.nlm.nih.gov/pubmed/34928377
http://dx.doi.org/10.1093/nar/gkab1248

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