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Alternative splicing modulation mediated by G-quadruplex structures in MALAT1 lncRNA

MALAT1, an abundant lncRNA specifically localized to nuclear speckles, regulates alternative-splicing (AS). The molecular basis of its role in AS remains poorly understood. Here, we report three conserved, thermodynamically stable, parallel RNA-G-quadruplexes (rG4s) present in the 3′ region of MALAT...

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Detalles Bibliográficos
Autores principales:	Ghosh, Arpita, Pandey, Satya Prakash, Ansari, Asgar Hussain, Sundar, Jennifer Seematti, Singh, Praveen, Khan, Yasmeen, Ekka, Mary Krishna, Chakraborty, Debojyoti, Maiti, Souvik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754661/ https://www.ncbi.nlm.nih.gov/pubmed/34761272 http://dx.doi.org/10.1093/nar/gkab1066

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