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Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery

Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory...

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Autores principales: MAESAWA, Satoshi, BAGARINAO, Epifanio, NAKATSUBO, Daisuke, ISHIZAKI, Tomotaka, TAKAI, Sou, TORII, Jun, KATO, Sachiko, SHIBATA, Masashi, WAKABAYASHI, Toshihiko, SAITO, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754678/
https://www.ncbi.nlm.nih.gov/pubmed/34759070
http://dx.doi.org/10.2176/nmc.oa.2021-0173
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author MAESAWA, Satoshi
BAGARINAO, Epifanio
NAKATSUBO, Daisuke
ISHIZAKI, Tomotaka
TAKAI, Sou
TORII, Jun
KATO, Sachiko
SHIBATA, Masashi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
author_facet MAESAWA, Satoshi
BAGARINAO, Epifanio
NAKATSUBO, Daisuke
ISHIZAKI, Tomotaka
TAKAI, Sou
TORII, Jun
KATO, Sachiko
SHIBATA, Masashi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
author_sort MAESAWA, Satoshi
collection PubMed
description Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory focal epilepsy, who subsequently underwent surgery. First, structural changes were examined using voxel-based morphometry analysis. Second, alterations in large-scale networks were evaluated using dual-regression analysis. Third, changes in cortical hubs were analyzed and the relationship between aberrant hubs and the epileptogenic zone (EZ) was evaluated. Finally, the relationship between the hubs and the default mode network (DMN) was examined using spectral dynamic causal modeling (spDCM). Dual-regression analysis revealed significant decrease in functional connectivity in several networks including DMN in patients, although no structural difference was seen between groups. Aberrant cortical hubs were observed in and around the EZ (EZ hubs) in 85% of the patients, and a strong degree of EZ hubs correlated to good seizure outcomes postoperatively. In spDCM analysis, facilitation was often seen from the EZ hub to the contralateral side, while inhibition was seen from the EZ hub to nodes of the DMN. Some cognition-related networks were impaired in patients with focal epilepsy. The EZ hub appeared in the vicinity of EZ facilitating connections to distant regions in the early phase, which may eventually generate secondary focus, while inhibiting connections to the DMN, which may cause cognitive deterioration. Our results demonstrate pathological network alterations in epilepsy and suggest that earlier surgical intervention may be more effective.
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spelling pubmed-87546782022-01-20 Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery MAESAWA, Satoshi BAGARINAO, Epifanio NAKATSUBO, Daisuke ISHIZAKI, Tomotaka TAKAI, Sou TORII, Jun KATO, Sachiko SHIBATA, Masashi WAKABAYASHI, Toshihiko SAITO, Ryuta Neurol Med Chir (Tokyo) Original Article Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory focal epilepsy, who subsequently underwent surgery. First, structural changes were examined using voxel-based morphometry analysis. Second, alterations in large-scale networks were evaluated using dual-regression analysis. Third, changes in cortical hubs were analyzed and the relationship between aberrant hubs and the epileptogenic zone (EZ) was evaluated. Finally, the relationship between the hubs and the default mode network (DMN) was examined using spectral dynamic causal modeling (spDCM). Dual-regression analysis revealed significant decrease in functional connectivity in several networks including DMN in patients, although no structural difference was seen between groups. Aberrant cortical hubs were observed in and around the EZ (EZ hubs) in 85% of the patients, and a strong degree of EZ hubs correlated to good seizure outcomes postoperatively. In spDCM analysis, facilitation was often seen from the EZ hub to the contralateral side, while inhibition was seen from the EZ hub to nodes of the DMN. Some cognition-related networks were impaired in patients with focal epilepsy. The EZ hub appeared in the vicinity of EZ facilitating connections to distant regions in the early phase, which may eventually generate secondary focus, while inhibiting connections to the DMN, which may cause cognitive deterioration. Our results demonstrate pathological network alterations in epilepsy and suggest that earlier surgical intervention may be more effective. The Japan Neurosurgical Society 2022-01 2021-11-10 /pmc/articles/PMC8754678/ /pubmed/34759070 http://dx.doi.org/10.2176/nmc.oa.2021-0173 Text en © 2022 The Japan Neurosurgical Society https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
MAESAWA, Satoshi
BAGARINAO, Epifanio
NAKATSUBO, Daisuke
ISHIZAKI, Tomotaka
TAKAI, Sou
TORII, Jun
KATO, Sachiko
SHIBATA, Masashi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title_full Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title_fullStr Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title_full_unstemmed Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title_short Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery
title_sort multitier network analysis using resting-state functional mri for epilepsy surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754678/
https://www.ncbi.nlm.nih.gov/pubmed/34759070
http://dx.doi.org/10.2176/nmc.oa.2021-0173
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