Heptad stereotypy, S/Q layering, and remote origin of the SARS-CoV-2 fusion core

The fusion of the SARS-CoV-2 virus with cells, a key event in the pathogenesis of Covid-19, depends on the assembly of a six-helix fusion core (FC) formed by portions of the spike protein heptad repeats (HRs) 1 and 2. Despite the critical role in regulating infectivity, its distinctive features, ori...

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Detalles Bibliográficos
Autores principales: Marchetti, Chiara, Vaglietti, Serena, Rizzo, Francesca, Di Nardo, Giovanna, Colnaghi, Luca, Ghirardi, Mirella, Fiumara, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754743/
https://www.ncbi.nlm.nih.gov/pubmed/35039783
http://dx.doi.org/10.1093/ve/veab097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754743/
https://www.ncbi.nlm.nih.gov/pubmed/35039783
http://dx.doi.org/10.1093/ve/veab097

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