Yearlong COVID-19 Infection Reveals Within-Host Evolution of SARS-CoV-2 in a Patient With B-Cell Depletion

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B-cell–depleting therapies may lead to prolonged disease and viral shedding in individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and this viral persistence raises concern for viral evolution. We report sequencing of early and late samples from a 335-day infection...

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Detalles Bibliográficos
Autores principales: Nussenblatt, Veronique, Roder, Allison E, Das, Sanchita, de Wit, Emmie, Youn, Jung-Ho, Banakis, Stephanie, Mushegian, Alexandra, Mederos, Christopher, Wang, Wei, Chung, Matthew, Pérez-Pérez, Lizzette, Palmore, Tara, Brudno, Jennifer N, Kochenderfer, James N, Ghedin, Elodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755281/
https://www.ncbi.nlm.nih.gov/pubmed/34940844
http://dx.doi.org/10.1093/infdis/jiab622
Descripción
Sumario:B-cell–depleting therapies may lead to prolonged disease and viral shedding in individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and this viral persistence raises concern for viral evolution. We report sequencing of early and late samples from a 335-day infection in an immunocompromised patient. The virus accumulated a unique deletion in the amino‐terminal domain of the spike protein, and complete deletion of ORF7b and ORF8, the first report of its kind in an immunocompromised patient. Unique viral mutations found in this study highlight the importance of analyzing viral evolution in protracted SARS-CoV-2 infection, especially in immunosuppressed hosts.

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