Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals

We have investigated the evolution of the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at 8 months after Pfizer-BNT162b2 vaccination in coronavirus disease 2019 (COVID-19)–naive (n = 21) and COVID-19–convalescent (n = 21) individuals. Neutralizi...

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Autores principales: Luczkowiak, Joanna, Labiod, Nuria, Rivas, Gonzalo, Rolo, Marta, Lasala, Fátima, Lora-Tamayo, Jaime, Mancheno-Losa, Mikel, Rial-Crestelo, David, Pérez-Rivilla, Alfredo, Folgueira, María Dolores, Delgado, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755312/
https://www.ncbi.nlm.nih.gov/pubmed/34963008
http://dx.doi.org/10.1093/infdis/jiab634
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author Luczkowiak, Joanna
Labiod, Nuria
Rivas, Gonzalo
Rolo, Marta
Lasala, Fátima
Lora-Tamayo, Jaime
Mancheno-Losa, Mikel
Rial-Crestelo, David
Pérez-Rivilla, Alfredo
Folgueira, María Dolores
Delgado, Rafael
author_facet Luczkowiak, Joanna
Labiod, Nuria
Rivas, Gonzalo
Rolo, Marta
Lasala, Fátima
Lora-Tamayo, Jaime
Mancheno-Losa, Mikel
Rial-Crestelo, David
Pérez-Rivilla, Alfredo
Folgueira, María Dolores
Delgado, Rafael
author_sort Luczkowiak, Joanna
collection PubMed
description We have investigated the evolution of the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at 8 months after Pfizer-BNT162b2 vaccination in coronavirus disease 2019 (COVID-19)–naive (n = 21) and COVID-19–convalescent (n = 21) individuals. Neutralizing levels declined for all variants (range 2- to 3.7-fold). Eight months after vaccination, a significant proportion (4/21) of naive individuals lacked detectable neutralizing activity against the highly transmissible SARS-CoV-2 delta variant. In the convalescent group, the impressive high initial humoral response resulted in detectable neutralizing antibody levels against all variants throughout this period.
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spelling pubmed-87553122022-01-13 Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals Luczkowiak, Joanna Labiod, Nuria Rivas, Gonzalo Rolo, Marta Lasala, Fátima Lora-Tamayo, Jaime Mancheno-Losa, Mikel Rial-Crestelo, David Pérez-Rivilla, Alfredo Folgueira, María Dolores Delgado, Rafael J Infect Dis Major Articles and Brief Reports We have investigated the evolution of the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at 8 months after Pfizer-BNT162b2 vaccination in coronavirus disease 2019 (COVID-19)–naive (n = 21) and COVID-19–convalescent (n = 21) individuals. Neutralizing levels declined for all variants (range 2- to 3.7-fold). Eight months after vaccination, a significant proportion (4/21) of naive individuals lacked detectable neutralizing activity against the highly transmissible SARS-CoV-2 delta variant. In the convalescent group, the impressive high initial humoral response resulted in detectable neutralizing antibody levels against all variants throughout this period. Oxford University Press 2021-12-28 /pmc/articles/PMC8755312/ /pubmed/34963008 http://dx.doi.org/10.1093/infdis/jiab634 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Luczkowiak, Joanna
Labiod, Nuria
Rivas, Gonzalo
Rolo, Marta
Lasala, Fátima
Lora-Tamayo, Jaime
Mancheno-Losa, Mikel
Rial-Crestelo, David
Pérez-Rivilla, Alfredo
Folgueira, María Dolores
Delgado, Rafael
Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title_full Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title_fullStr Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title_full_unstemmed Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title_short Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals
title_sort neutralizing response against sars-cov-2 variants 8 months after bnt162b2 vaccination in naive and covid-19–convalescent individuals
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755312/
https://www.ncbi.nlm.nih.gov/pubmed/34963008
http://dx.doi.org/10.1093/infdis/jiab634
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