Cancer biology and molecular genetics of A(3) adenosine receptor

A(3) adenosine receptor (A(3)AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A(3)AR has a dual nature in different pathophysiological conditions, a...

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Autores principales: Mazziotta, Chiara, Rotondo, John Charles, Lanzillotti, Carmen, Campione, Giulia, Martini, Fernanda, Tognon, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755539/
https://www.ncbi.nlm.nih.gov/pubmed/34750517
http://dx.doi.org/10.1038/s41388-021-02090-z
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author Mazziotta, Chiara
Rotondo, John Charles
Lanzillotti, Carmen
Campione, Giulia
Martini, Fernanda
Tognon, Mauro
author_facet Mazziotta, Chiara
Rotondo, John Charles
Lanzillotti, Carmen
Campione, Giulia
Martini, Fernanda
Tognon, Mauro
author_sort Mazziotta, Chiara
collection PubMed
description A(3) adenosine receptor (A(3)AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A(3)AR has a dual nature in different pathophysiological conditions, as it is expressed according to tissue type and stimulated by an adenosine dose-dependent manner. A(3)AR activation leads to tumor growth, cell proliferation and survival in some cases, while triggering cytostatic and apoptotic pathways in others. This review aims to describe the most relevant aspects of A(3)AR activation and its ligands whereas it summarizes A(3)AR activities in cancer. Progress in the field of A(3)AR modulators, with a potential therapeutic role in cancer treatment are reported, as well.
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spelling pubmed-87555392022-01-26 Cancer biology and molecular genetics of A(3) adenosine receptor Mazziotta, Chiara Rotondo, John Charles Lanzillotti, Carmen Campione, Giulia Martini, Fernanda Tognon, Mauro Oncogene Review Article A(3) adenosine receptor (A(3)AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A(3)AR has a dual nature in different pathophysiological conditions, as it is expressed according to tissue type and stimulated by an adenosine dose-dependent manner. A(3)AR activation leads to tumor growth, cell proliferation and survival in some cases, while triggering cytostatic and apoptotic pathways in others. This review aims to describe the most relevant aspects of A(3)AR activation and its ligands whereas it summarizes A(3)AR activities in cancer. Progress in the field of A(3)AR modulators, with a potential therapeutic role in cancer treatment are reported, as well. Nature Publishing Group UK 2021-11-08 2022 /pmc/articles/PMC8755539/ /pubmed/34750517 http://dx.doi.org/10.1038/s41388-021-02090-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Mazziotta, Chiara
Rotondo, John Charles
Lanzillotti, Carmen
Campione, Giulia
Martini, Fernanda
Tognon, Mauro
Cancer biology and molecular genetics of A(3) adenosine receptor
title Cancer biology and molecular genetics of A(3) adenosine receptor
title_full Cancer biology and molecular genetics of A(3) adenosine receptor
title_fullStr Cancer biology and molecular genetics of A(3) adenosine receptor
title_full_unstemmed Cancer biology and molecular genetics of A(3) adenosine receptor
title_short Cancer biology and molecular genetics of A(3) adenosine receptor
title_sort cancer biology and molecular genetics of a(3) adenosine receptor
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755539/
https://www.ncbi.nlm.nih.gov/pubmed/34750517
http://dx.doi.org/10.1038/s41388-021-02090-z
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