The role of GTPase-activating protein ARHGAP26 in human cancers

Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. It also affe...

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Autores principales: Zhang, Lingye, Zhou, Anni, Zhu, Shengtao, Min, Li, Liu, Si, Li, Peng, Zhang, Shutian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755663/
https://www.ncbi.nlm.nih.gov/pubmed/34716859
http://dx.doi.org/10.1007/s11010-021-04274-3
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author Zhang, Lingye
Zhou, Anni
Zhu, Shengtao
Min, Li
Liu, Si
Li, Peng
Zhang, Shutian
author_facet Zhang, Lingye
Zhou, Anni
Zhu, Shengtao
Min, Li
Liu, Si
Li, Peng
Zhang, Shutian
author_sort Zhang, Lingye
collection PubMed
description Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. It also affects tumorigenesis and progression of various tumors through several methods, including formation of abnormal fusion genes and circular RNA. This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
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spelling pubmed-87556632022-01-20 The role of GTPase-activating protein ARHGAP26 in human cancers Zhang, Lingye Zhou, Anni Zhu, Shengtao Min, Li Liu, Si Li, Peng Zhang, Shutian Mol Cell Biochem Article Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. It also affects tumorigenesis and progression of various tumors through several methods, including formation of abnormal fusion genes and circular RNA. This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed. Springer US 2021-10-30 2022 /pmc/articles/PMC8755663/ /pubmed/34716859 http://dx.doi.org/10.1007/s11010-021-04274-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Lingye
Zhou, Anni
Zhu, Shengtao
Min, Li
Liu, Si
Li, Peng
Zhang, Shutian
The role of GTPase-activating protein ARHGAP26 in human cancers
title The role of GTPase-activating protein ARHGAP26 in human cancers
title_full The role of GTPase-activating protein ARHGAP26 in human cancers
title_fullStr The role of GTPase-activating protein ARHGAP26 in human cancers
title_full_unstemmed The role of GTPase-activating protein ARHGAP26 in human cancers
title_short The role of GTPase-activating protein ARHGAP26 in human cancers
title_sort role of gtpase-activating protein arhgap26 in human cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755663/
https://www.ncbi.nlm.nih.gov/pubmed/34716859
http://dx.doi.org/10.1007/s11010-021-04274-3
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