DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster

The nonhomologous end-joining pathway is a primary DNA double-strand break repair pathway in eukaryotes. DNA ligase IV (Lig4) catalyzes the final step of DNA end ligation in this pathway. Partial loss of Lig4 in mammals causes Lig4 syndrome, while complete loss is embryonically lethal. DNA ligase 4...

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Detalles Bibliográficos
Autores principales: Joshi, Rashmi, Banerjee, Surya Jyoti, Curtiss, Jennifer, Ashley, Amanda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Animal Genetics • Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755683/
https://www.ncbi.nlm.nih.gov/pubmed/34817771
http://dx.doi.org/10.1007/s13353-021-00637-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755683/
https://www.ncbi.nlm.nih.gov/pubmed/34817771
http://dx.doi.org/10.1007/s13353-021-00637-0

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