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Chronic kidney disease impairs prognosis in electrical storm

BACKGROUND: The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a life-threatening heart rhythm disorder. In particular, CKD patients are at risk of suffering from ES. However, data regarding the prognostic impact of...

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Autores principales: Weidner, Kathrin, Behnes, Michael, Schupp, Tobias, Hoppner, Jorge, Ansari, Uzair, Mueller, Julian, Lindner, Simon, Borggrefe, Martin, Kim, Seung-hyun, Huseyinov, Aydin, Ellguth, Dominik, Akin, Muharrem, Meininghaus, Dirk Große, Bertsch, Thomas, Taton, Gabriel, Bollow, Armin, Reichelt, Thomas, Engelke, Niko, Reiser, Linda, Akin, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755690/
https://www.ncbi.nlm.nih.gov/pubmed/33483805
http://dx.doi.org/10.1007/s10840-020-00924-6
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author Weidner, Kathrin
Behnes, Michael
Schupp, Tobias
Hoppner, Jorge
Ansari, Uzair
Mueller, Julian
Lindner, Simon
Borggrefe, Martin
Kim, Seung-hyun
Huseyinov, Aydin
Ellguth, Dominik
Akin, Muharrem
Meininghaus, Dirk Große
Bertsch, Thomas
Taton, Gabriel
Bollow, Armin
Reichelt, Thomas
Engelke, Niko
Reiser, Linda
Akin, Ibrahim
author_facet Weidner, Kathrin
Behnes, Michael
Schupp, Tobias
Hoppner, Jorge
Ansari, Uzair
Mueller, Julian
Lindner, Simon
Borggrefe, Martin
Kim, Seung-hyun
Huseyinov, Aydin
Ellguth, Dominik
Akin, Muharrem
Meininghaus, Dirk Große
Bertsch, Thomas
Taton, Gabriel
Bollow, Armin
Reichelt, Thomas
Engelke, Niko
Reiser, Linda
Akin, Ibrahim
author_sort Weidner, Kathrin
collection PubMed
description BACKGROUND: The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a life-threatening heart rhythm disorder. In particular, CKD patients are at risk of suffering from ES. However, data regarding the prognostic impact of CKD on long-term mortality in ES patients is limited. METHODS: All consecutive ES patients with an implantable cardioverter–defibrillator (ICD) were included retrospectively from 2002 to 2016. Patients with CKD (MDRD-GFR < 60 ml/min/1.73 m(2)) were compared to patients without CKD. The primary endpoint was all-cause mortality at 3 years. Secondary endpoints were in-hospital mortality, cardiac rehospitalization, recurrences of electrical storm (ES-R), and major adverse cardiac events (MACE) at 3 years. RESULTS: A total of 70 consecutive ES patients were included. CKD was present in 43% of ES patients with a median glomerular filtration rate (GFR) of 43.3 ml/min/1.73 m(2). CKD was associated with increased all-cause mortality at 3 years (63% vs. 20%; p = 0.001; HR = 4.293; 95% CI 1.874–9.836; p = 0.001) and MACE (57% vs. 30%; p = 0.025; HR = 3.597; 95% CI 1.679–7.708; p = 0.001). In contrast, first cardiac rehospitalization (43% vs. 45%; log-rank p = 0.889) and ES-R (30% vs. 20%; log-rank p = 0.334) were not affected by CKD. Even after multivariable adjustment, CKD was still associated with increased long-term mortality (HR = 2.397; 95% CI 1.012–5.697; p = 0.047), as well as with the secondary endpoint MACE (HR = 2.520; 95% CI 1.109–5.727; p = 0.027). CONCLUSIONS: In patients with ES, the presence of CKD was associated with increased long-term mortality and MACE.
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spelling pubmed-87556902022-01-20 Chronic kidney disease impairs prognosis in electrical storm Weidner, Kathrin Behnes, Michael Schupp, Tobias Hoppner, Jorge Ansari, Uzair Mueller, Julian Lindner, Simon Borggrefe, Martin Kim, Seung-hyun Huseyinov, Aydin Ellguth, Dominik Akin, Muharrem Meininghaus, Dirk Große Bertsch, Thomas Taton, Gabriel Bollow, Armin Reichelt, Thomas Engelke, Niko Reiser, Linda Akin, Ibrahim J Interv Card Electrophysiol Article BACKGROUND: The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a life-threatening heart rhythm disorder. In particular, CKD patients are at risk of suffering from ES. However, data regarding the prognostic impact of CKD on long-term mortality in ES patients is limited. METHODS: All consecutive ES patients with an implantable cardioverter–defibrillator (ICD) were included retrospectively from 2002 to 2016. Patients with CKD (MDRD-GFR < 60 ml/min/1.73 m(2)) were compared to patients without CKD. The primary endpoint was all-cause mortality at 3 years. Secondary endpoints were in-hospital mortality, cardiac rehospitalization, recurrences of electrical storm (ES-R), and major adverse cardiac events (MACE) at 3 years. RESULTS: A total of 70 consecutive ES patients were included. CKD was present in 43% of ES patients with a median glomerular filtration rate (GFR) of 43.3 ml/min/1.73 m(2). CKD was associated with increased all-cause mortality at 3 years (63% vs. 20%; p = 0.001; HR = 4.293; 95% CI 1.874–9.836; p = 0.001) and MACE (57% vs. 30%; p = 0.025; HR = 3.597; 95% CI 1.679–7.708; p = 0.001). In contrast, first cardiac rehospitalization (43% vs. 45%; log-rank p = 0.889) and ES-R (30% vs. 20%; log-rank p = 0.334) were not affected by CKD. Even after multivariable adjustment, CKD was still associated with increased long-term mortality (HR = 2.397; 95% CI 1.012–5.697; p = 0.047), as well as with the secondary endpoint MACE (HR = 2.520; 95% CI 1.109–5.727; p = 0.027). CONCLUSIONS: In patients with ES, the presence of CKD was associated with increased long-term mortality and MACE. Springer US 2021-01-23 2022 /pmc/articles/PMC8755690/ /pubmed/33483805 http://dx.doi.org/10.1007/s10840-020-00924-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Weidner, Kathrin
Behnes, Michael
Schupp, Tobias
Hoppner, Jorge
Ansari, Uzair
Mueller, Julian
Lindner, Simon
Borggrefe, Martin
Kim, Seung-hyun
Huseyinov, Aydin
Ellguth, Dominik
Akin, Muharrem
Meininghaus, Dirk Große
Bertsch, Thomas
Taton, Gabriel
Bollow, Armin
Reichelt, Thomas
Engelke, Niko
Reiser, Linda
Akin, Ibrahim
Chronic kidney disease impairs prognosis in electrical storm
title Chronic kidney disease impairs prognosis in electrical storm
title_full Chronic kidney disease impairs prognosis in electrical storm
title_fullStr Chronic kidney disease impairs prognosis in electrical storm
title_full_unstemmed Chronic kidney disease impairs prognosis in electrical storm
title_short Chronic kidney disease impairs prognosis in electrical storm
title_sort chronic kidney disease impairs prognosis in electrical storm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755690/
https://www.ncbi.nlm.nih.gov/pubmed/33483805
http://dx.doi.org/10.1007/s10840-020-00924-6
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