Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma

SUMOylation is a post-translational modification of proteins that regulates these proteins’ localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide transposon mutagenesis screen in a MYC-driven B-cell lymphoma model,...

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Detalles Bibliográficos
Autores principales: Schick, Markus, Zhang, Le, Maurer, Sabine, Maurer, Hans Carlo, Isaakaidis, Konstandina, Schneider, Lara, Patra, Upayan, Schunck, Kathrin, Rohleder, Elena, Hofstetter, Julia, Baluapuri, Apoorva, Scherger, Anna Katharina, Slotta-Huspenina, Julia, Hettler, Franziska, Weber, Julia, Engleitner, Thomas, Maresch, Roman, Slawska, Jolanta, Lewis, Richard, Istvanffy, Rouzanna, Habringer, Stefan, Steiger, Katja, Baiker, Armin, Oostendorp, Robert A. J., Miething, Cornelius, Lenhof, Hans-Peter, Bassermann, Florian, Chapuy, Björn, Wirth, Matthias, Wolf, Elmar, Rad, Roland, Müller, Stefan, Keller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755833/
https://www.ncbi.nlm.nih.gov/pubmed/35022408
http://dx.doi.org/10.1038/s41467-021-27704-8

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