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Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer

The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. Fifty-two patients who received rotating gantr...

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Autores principales: Tatsuno, Saori, Doi, Hiroshi, Okada, Wataru, Inoue, Eri, Nakamatsu, Kiyoshi, Tanooka, Masao, Tanaka, Masahiro, Nishimura, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755838/
https://www.ncbi.nlm.nih.gov/pubmed/35022506
http://dx.doi.org/10.1038/s41598-021-04601-0
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author Tatsuno, Saori
Doi, Hiroshi
Okada, Wataru
Inoue, Eri
Nakamatsu, Kiyoshi
Tanooka, Masao
Tanaka, Masahiro
Nishimura, Yasumasa
author_facet Tatsuno, Saori
Doi, Hiroshi
Okada, Wataru
Inoue, Eri
Nakamatsu, Kiyoshi
Tanooka, Masao
Tanaka, Masahiro
Nishimura, Yasumasa
author_sort Tatsuno, Saori
collection PubMed
description The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. Fifty-two patients who received rotating gantry IMRT for locally advanced lung cancer were included in this retrospective study. In total, 31 and 21 patients received VMAT and HT, respectively. The median follow-up duration was 14 months (range, 5.2–33.6). Twenty (38%) and eight (15%) patients developed grade ≥ 2 and ≥ 3 RP, respectively. In multivariate analysis, lung V5 ≥ 40% was associated with grade ≥ 2 RP (P = 0.02), and past medical history of pneumonectomy and total lung volume ≤ 3260 cc were independently associated with grade ≥ 3 RP (P = 0.02 and P = 0.03, respectively). Rotating gantry IMRT was feasible and safe in patients with lung cancer undergoing definitive radiotherapy. Reducing lung V5 may decrease the risk of symptomatic RP, and care should be taken to avoid severe RP after radiotherapy in patients with a past medical history of pneumonectomy and small total lung volume.
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spelling pubmed-87558382022-01-14 Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer Tatsuno, Saori Doi, Hiroshi Okada, Wataru Inoue, Eri Nakamatsu, Kiyoshi Tanooka, Masao Tanaka, Masahiro Nishimura, Yasumasa Sci Rep Article The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. Fifty-two patients who received rotating gantry IMRT for locally advanced lung cancer were included in this retrospective study. In total, 31 and 21 patients received VMAT and HT, respectively. The median follow-up duration was 14 months (range, 5.2–33.6). Twenty (38%) and eight (15%) patients developed grade ≥ 2 and ≥ 3 RP, respectively. In multivariate analysis, lung V5 ≥ 40% was associated with grade ≥ 2 RP (P = 0.02), and past medical history of pneumonectomy and total lung volume ≤ 3260 cc were independently associated with grade ≥ 3 RP (P = 0.02 and P = 0.03, respectively). Rotating gantry IMRT was feasible and safe in patients with lung cancer undergoing definitive radiotherapy. Reducing lung V5 may decrease the risk of symptomatic RP, and care should be taken to avoid severe RP after radiotherapy in patients with a past medical history of pneumonectomy and small total lung volume. Nature Publishing Group UK 2022-01-12 /pmc/articles/PMC8755838/ /pubmed/35022506 http://dx.doi.org/10.1038/s41598-021-04601-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tatsuno, Saori
Doi, Hiroshi
Okada, Wataru
Inoue, Eri
Nakamatsu, Kiyoshi
Tanooka, Masao
Tanaka, Masahiro
Nishimura, Yasumasa
Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title_full Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title_fullStr Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title_full_unstemmed Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title_short Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
title_sort risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755838/
https://www.ncbi.nlm.nih.gov/pubmed/35022506
http://dx.doi.org/10.1038/s41598-021-04601-0
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