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Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group
PURPOSE: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. MATERIALS AND METHODS: Seventy-nine pediatric...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Cancer Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756110/ https://www.ncbi.nlm.nih.gov/pubmed/33887821 http://dx.doi.org/10.4143/crt.2021.313 |
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author | Park, Kyung Mi Yoo, Keon Hee Kim, Seong Koo Lee, Jae Wook Chung, Nack-Gyun Ju, Hee Young Koo, Hong Hoe Lyu, Chuhl Joo Han, Seung Min Han, Jung Woo Choi, Jung Yoon Hong, Kyung Taek Kang, Hyoung Jin Shin, Hee Young Im, Ho Joon Koh, Kyung-Nam Kim, Hyery Kook, Hoon Baek, Hee Jo Kim, Bo Ram Yang, Eu Jeen Lim, Jae Young Park, Eun Sil Choi, Eun Jin Park, Sang Kyu Lee, Jae Min Shim, Ye Jee Kim, Ji Yoon Park, Ji Kyoung Kong, Seom Gim Choi, Young Bae Cho, Bin Lim, Young Tak |
author_facet | Park, Kyung Mi Yoo, Keon Hee Kim, Seong Koo Lee, Jae Wook Chung, Nack-Gyun Ju, Hee Young Koo, Hong Hoe Lyu, Chuhl Joo Han, Seung Min Han, Jung Woo Choi, Jung Yoon Hong, Kyung Taek Kang, Hyoung Jin Shin, Hee Young Im, Ho Joon Koh, Kyung-Nam Kim, Hyery Kook, Hoon Baek, Hee Jo Kim, Bo Ram Yang, Eu Jeen Lim, Jae Young Park, Eun Sil Choi, Eun Jin Park, Sang Kyu Lee, Jae Min Shim, Ye Jee Kim, Ji Yoon Park, Ji Kyoung Kong, Seom Gim Choi, Young Bae Cho, Bin Lim, Young Tak |
author_sort | Park, Kyung Mi |
collection | PubMed |
description | PURPOSE: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. MATERIALS AND METHODS: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. RESULTS: Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×10(9)/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×10(9)/L than in those with initial WBC ≥ 10×10(9)/L (p=0.020). CONCLUSION: This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment. |
format | Online Article Text |
id | pubmed-8756110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-87561102022-01-25 Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group Park, Kyung Mi Yoo, Keon Hee Kim, Seong Koo Lee, Jae Wook Chung, Nack-Gyun Ju, Hee Young Koo, Hong Hoe Lyu, Chuhl Joo Han, Seung Min Han, Jung Woo Choi, Jung Yoon Hong, Kyung Taek Kang, Hyoung Jin Shin, Hee Young Im, Ho Joon Koh, Kyung-Nam Kim, Hyery Kook, Hoon Baek, Hee Jo Kim, Bo Ram Yang, Eu Jeen Lim, Jae Young Park, Eun Sil Choi, Eun Jin Park, Sang Kyu Lee, Jae Min Shim, Ye Jee Kim, Ji Yoon Park, Ji Kyoung Kong, Seom Gim Choi, Young Bae Cho, Bin Lim, Young Tak Cancer Res Treat Original Article PURPOSE: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. MATERIALS AND METHODS: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. RESULTS: Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×10(9)/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×10(9)/L than in those with initial WBC ≥ 10×10(9)/L (p=0.020). CONCLUSION: This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment. Korean Cancer Association 2022-01 2021-04-20 /pmc/articles/PMC8756110/ /pubmed/33887821 http://dx.doi.org/10.4143/crt.2021.313 Text en Copyright © 2022 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Kyung Mi Yoo, Keon Hee Kim, Seong Koo Lee, Jae Wook Chung, Nack-Gyun Ju, Hee Young Koo, Hong Hoe Lyu, Chuhl Joo Han, Seung Min Han, Jung Woo Choi, Jung Yoon Hong, Kyung Taek Kang, Hyoung Jin Shin, Hee Young Im, Ho Joon Koh, Kyung-Nam Kim, Hyery Kook, Hoon Baek, Hee Jo Kim, Bo Ram Yang, Eu Jeen Lim, Jae Young Park, Eun Sil Choi, Eun Jin Park, Sang Kyu Lee, Jae Min Shim, Ye Jee Kim, Ji Yoon Park, Ji Kyoung Kong, Seom Gim Choi, Young Bae Cho, Bin Lim, Young Tak Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title_full | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title_fullStr | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title_full_unstemmed | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title_short | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group |
title_sort | clinical characteristics and treatment outcomes of childhood acute promyelocytic leukemia in korea: a nationwide multicenter retrospective study by korean pediatric oncology study group |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756110/ https://www.ncbi.nlm.nih.gov/pubmed/33887821 http://dx.doi.org/10.4143/crt.2021.313 |
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