Cargando…

Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations

PURPOSE: Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in treatment outcome after RT. MATERIALS AND METHODS: Patients with solid tumor who participated in next gene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Kyung Hwan, Kim, Han Sang, Kim, Seung-seob, Shim, Hyo Sup, Yang, Andrew Jihoon, Lee, Jason Joon Bock, Yoon, Hong In, Ahn, Joong Bae, Chang, Jee Suk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Cancer Association 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756123/ https://www.ncbi.nlm.nih.gov/pubmed/34082492 http://dx.doi.org/10.4143/crt.2020.1247

Ejemplares similares

Low levels of ATM in breast cancer patients with clinical radiosensitivity
por: Fang, Zhiming, et al.
Publicado: (2010)

Avelumab Plus Talazoparib in Patients With BRCA1/2- or ATM-Altered Advanced Solid Tumors: Results From JAVELIN BRCA/ATM, an Open-Label, Multicenter, Phase 2b, Tumor-Agnostic Trial
por: Schram, Alison M., et al.
Publicado: (2022)

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
por: Hussain, Rumana N., et al.
Publicado: (2020)

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity
por: Dohmen, Amy J.C., et al.
Publicado: (2017)

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?
por: El Nachef, Laura, et al.
Publicado: (2022)

ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis
por: Tew, Ben Yi, et al.
Publicado: (2023)

Wip1 and ATM in tumor evolution: role for BRCA1
por: Filipponi, Doria, et al.
Publicado: (2013)

Downregulation of ATM and BRCA1 Predicts Poor Outcome in Head and Neck Cancer: Implications for ATM-Targeted Therapy
por: Wang, Yu-Chu, et al.
Publicado: (2021)

Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM
por: Pan, Shu-Ting, et al.
Publicado: (2021)

Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase
por: Al-Choboq, Joëlle, et al.
Publicado: (2022)

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
por: Baert, Annelot, et al.
Publicado: (2016)

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity
por: Wang, Jufang, et al.
Publicado: (2011)

Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations
por: Lee, Jii Bum, et al.
Publicado: (2021)

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay
por: Baert, Annelot, et al.
Publicado: (2017)

Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells
por: Kim, Han Sang, et al.
Publicado: (2012)

Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation
por: Kim, Yong Hwan, et al.
Publicado: (2022)

Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice
por: Zou, Jian, et al.
Publicado: (2008)

EphA5 Silencing Increases the Radiosensitivity of ESCC Cells Through ATM-Dependent Pathway
por: Zhang, Rui, et al.
Publicado: (2020)

The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma
por: Stewart, Connor E., et al.
Publicado: (2022)

Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound
por: Chi, Kim N., et al.
Publicado: (2023)

Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis
por: Su, Fengtao, et al.
Publicado: (2010)

Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
por: Qi, Leilei, et al.
Publicado: (2022)

Metastatic malignant solid pseudopapillary tumor of the pancreas
por: Kim, Jun Jae, et al.
Publicado: (2013)

Mutation at Intronic Repeats of the Ataxia-Telangiectasia Mutated (ATM) Gene and ATM Protein Loss in Primary Gastric Cancer with Microsatellite Instability
por: Kim, Hee Sung, et al.
Publicado: (2013)

Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays
por: Sadeghi, Fatemeh, et al.
Publicado: (2020)

Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA
por: Matsubara, Nobuaki, et al.
Publicado: (2023)

Influence of Individual Radiosensitivity on the Hormesis Phenomenon: Toward a Mechanistic Explanation Based on the Nucleoshuttling of ATM Protein
por: Devic, Clément, et al.
Publicado: (2020)

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells
por: Schleicher, Emily M., et al.
Publicado: (2022)

Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1
por: Baloch, Tahira, et al.
Publicado: (2019)

Comparison of radiosensitivity response to acute and chronic gamma irradiation in colored wheat
por: Hong, Min Jeong, et al.
Publicado: (2018)

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
por: Durant, Stephen T., et al.
Publicado: (2018)

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells
por: Royba, Ekaterina, et al.
Publicado: (2017)

Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
por: Scheper, Julian, et al.
Publicado: (2022)

Gold nanoparticles as a potent radiosensitizer in neutron therapy
por: Kim, Eun Ho, et al.
Publicado: (2017)

Gene Expression Profiling Identifies Akt as a Target for Radiosensitization in Gastric Cancer Cells
por: Kim, Kyung Hwan, et al.
Publicado: (2020)

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
por: Ratz, Leonie, et al.
Publicado: (2022)

Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity
por: Bu, Rong, et al.
Publicado: (2023)

Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.
por: Sheldon, P. W., et al.
Publicado: (1975)

Gastrointestinal malignancies harbor actionable MET exon 14 deletions
por: Lee, Jeeyun, et al.
Publicado: (2015)

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
por: Abida, Wassim, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vmkmm6m3v3gijoho0hmnl2nkqv