Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer

PURPOSE: To evaluate the mechanisms of how therapeutic upregulation of the transcription factor, CCAAT/enhancer-binding protein alpha (C/EBPα), prevents tumor progression in patients with advanced hepatocellular carcinoma (HCC) and in different mouse tumor models. EXPERIMENTAL DESIGN: We conducted a...

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Detalles Bibliográficos
Autores principales: Hashimoto, Ayumi, Sarker, Debashis, Reebye, Vikash, Jarvis, Sheba, Sodergren, Mikael H., Kossenkov, Andrew, Sanseviero, Emilio, Raulf, Nina, Vasara, Jenni, Andrikakou, Pinelopi, Meyer, Tim, Huang, Kai-Wen, Plummer, Ruth, Chee, Cheng E., Spalding, Duncan, Pai, Madhava, Khan, Shahid, Pinato, David J., Sharma, Rohini, Basu, Bristi, Palmer, Daniel, Ma, Yuk-Ting, Evans, Jeff, Habib, Robert, Martirosyan, Anna, Elasri, Naouel, Reynaud, Adeline, Rossi, John J., Cobbold, Mark, Habib, Nagy A., Gabrilovich, Dmitry I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756351/
https://www.ncbi.nlm.nih.gov/pubmed/34407972
http://dx.doi.org/10.1158/1078-0432.CCR-21-0986

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