Substratum stiffness regulates Erk signaling dynamics through receptor-level control

The EGFR/Erk pathway is triggered by extracellular ligand stimulation, leading to stimulus-dependent dynamics of pathway activity. Although mechanical properties of the microenvironment also affect Erk activity, their effects on Erk signaling dynamics are poorly understood. Here, we characterize how...

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Detalles Bibliográficos
Autores principales: Farahani, Payam E., Lemke, Sandra B., Dine, Elliot, Uribe, Giselle, Toettcher, Jared E., Nelson, Celeste M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756379/
https://www.ncbi.nlm.nih.gov/pubmed/34965432
http://dx.doi.org/10.1016/j.celrep.2021.110181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756379/
https://www.ncbi.nlm.nih.gov/pubmed/34965432
http://dx.doi.org/10.1016/j.celrep.2021.110181

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