Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis

Homozygotes for the higher penetrance hemochromatosis risk allele, HFE c.845G>A (p.Cys282Tyr, or C282Y), have been reported to be at a 2- to 3-fold increased risk for colorectal cancer (CRC). These results have been reported for small sample size studies with no information about age at diagnosis...

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Detalles Bibliográficos
Autores principales: Jarvik, Gail P., Wang, Xiaoliang, Fontanillas, Pierre, Kim, Esther, Chanprasert, Sirisak, Gordon, Adam S., Bastarache, Lisa, Kowdley, Kris V., Harrison, Tabitha, Rosenthal, Elisabeth A., Stanaway, Ian B., Bézieau, Stéphane, Weinstein, Stephanie J., Newcomb, Polly A., Casey, Graham, Platz, Elizabeth A., Visvanathan, Kala, Le Marchand, Loic, Ulrich, Cornelia M., Hardikar, Sheetal, Li, Christopher I., van Duijnhoven, Franzel J.B., Gsur, Andrea, Campbell, Peter T., Moreno, Victor, Vodička, Pavel, Brenner, Hermann, Chang-Claude, Jenny, Hoffmeister, Michael, Slattery, Martha L., Gunter, Marc J., Aglago, Elom K., Castellví-Bel, Sergi, Kweon, Sun-Seog, Chan, Andrew T., Li, Li, Zheng, Wei, Bishop, D. Timothy, Giles, Graham G., Rennert, Gad, Offit, Kenneth, Keku, Temitope O., Woods, Michael O., Hampe, Jochen, Van Guelpen, Bethan, Gallinger, Steven J., de la Chapelle, Albert, Hampel, Heather, Berndt, Sonja I., Tangen, Catherine M., Lindblom, Annika, Wolk, Alicja, Burnett-Hartman, Andrea, Wu, Anna H., White, Emily, Gruber, Stephen B., Jenkins, Mark A., Mountain, Joanna, Peters, Ulrike, Crosslin, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756515/
https://www.ncbi.nlm.nih.gov/pubmed/35047832
http://dx.doi.org/10.1016/j.xhgg.2020.100010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756515/
https://www.ncbi.nlm.nih.gov/pubmed/35047832
http://dx.doi.org/10.1016/j.xhgg.2020.100010

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