Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

BACKGROUND: High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme dosed at 50 units (u)/kg, resulting in rapid systemic MT...

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Detalles Bibliográficos
Autores principales: Schaff, Lauren R., Lobbous, Mina, Carlow, Dean, Schofield, Ryan, Gavrilovic, Igor T., Miller, Alexandra M., Stone, Jacqueline B., Piotrowski, Anna F., Sener, Ugur, Skakodub, Anna, Acosta, Edward P., Ryan, Kevin J., Mellinghoff, Ingo K., DeAngelis, Lisa M., Nabors, Louis B., Grommes, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756618/
https://www.ncbi.nlm.nih.gov/pubmed/35027038
http://dx.doi.org/10.1186/s12885-021-09164-x

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