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Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review

People living with HIV (PLWH) are particularly vulnerable to worsened outcomes of COVID-19. Therefore, the purpose of this work was to provide a scoping review of the literature to assess the risk factors for COVID-19 mortality among PLWH. Following the Preferred Reporting Items for Systematic Revie...

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Autores principales: Varshney, Karan, Ghosh, Prerana, Stiles, Helena, Iriowen, Rosemary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756751/
https://www.ncbi.nlm.nih.gov/pubmed/35024992
http://dx.doi.org/10.1007/s10461-022-03578-9
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author Varshney, Karan
Ghosh, Prerana
Stiles, Helena
Iriowen, Rosemary
author_facet Varshney, Karan
Ghosh, Prerana
Stiles, Helena
Iriowen, Rosemary
author_sort Varshney, Karan
collection PubMed
description People living with HIV (PLWH) are particularly vulnerable to worsened outcomes of COVID-19. Therefore, the purpose of this work was to provide a scoping review of the literature to assess the risk factors for COVID-19 mortality among PLWH. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), searches were conducted in PubMed, Scopus, Global Health, and WHO Coronavirus Database. Articles were eligible for inclusion if they were in English, included PLWH who died after COVID-19 infection, and described risk factors for mortality. Results were descriptively synthesized and pooled thereafter. Study quality was assessed using the Joanna Brigg Institute’s critical appraisal tools. 20 studies were eligible for inclusion, with the pooled death rate being 11.7%. Age was a major risk factor, especially after 50 (23.2%) and after 70 (41.8%), and males had a death rate nearly double that of females. As total comorbidities increased, the death rate also greatly increased; among those with comorbidities, the highest fatality rates were those with cardiovascular disease (30.2%), chronic kidney disease (23.5%), obesity (22.4%), and diabetes (18.4%). Other risk factors for mortality among PLWH included having a Black racial background, being an injection drug user, being a smoker, and having a CD4 cell count below 200. There is a need to better study confounding factors, and to understand how vaccination influences mortality risk. Overall, the findings highlight a need to ensure that focus is placed on the varying demographics of PLWH amidst COVID-19 control efforts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10461-022-03578-9.
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spelling pubmed-87567512022-01-14 Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review Varshney, Karan Ghosh, Prerana Stiles, Helena Iriowen, Rosemary AIDS Behav Substantive Review People living with HIV (PLWH) are particularly vulnerable to worsened outcomes of COVID-19. Therefore, the purpose of this work was to provide a scoping review of the literature to assess the risk factors for COVID-19 mortality among PLWH. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), searches were conducted in PubMed, Scopus, Global Health, and WHO Coronavirus Database. Articles were eligible for inclusion if they were in English, included PLWH who died after COVID-19 infection, and described risk factors for mortality. Results were descriptively synthesized and pooled thereafter. Study quality was assessed using the Joanna Brigg Institute’s critical appraisal tools. 20 studies were eligible for inclusion, with the pooled death rate being 11.7%. Age was a major risk factor, especially after 50 (23.2%) and after 70 (41.8%), and males had a death rate nearly double that of females. As total comorbidities increased, the death rate also greatly increased; among those with comorbidities, the highest fatality rates were those with cardiovascular disease (30.2%), chronic kidney disease (23.5%), obesity (22.4%), and diabetes (18.4%). Other risk factors for mortality among PLWH included having a Black racial background, being an injection drug user, being a smoker, and having a CD4 cell count below 200. There is a need to better study confounding factors, and to understand how vaccination influences mortality risk. Overall, the findings highlight a need to ensure that focus is placed on the varying demographics of PLWH amidst COVID-19 control efforts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10461-022-03578-9. Springer US 2022-01-13 2022 /pmc/articles/PMC8756751/ /pubmed/35024992 http://dx.doi.org/10.1007/s10461-022-03578-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Substantive Review
Varshney, Karan
Ghosh, Prerana
Stiles, Helena
Iriowen, Rosemary
Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title_full Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title_fullStr Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title_full_unstemmed Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title_short Risk Factors for COVID-19 Mortality Among People Living with HIV: A Scoping Review
title_sort risk factors for covid-19 mortality among people living with hiv: a scoping review
topic Substantive Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756751/
https://www.ncbi.nlm.nih.gov/pubmed/35024992
http://dx.doi.org/10.1007/s10461-022-03578-9
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