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Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure

[Image: see text] In this paper, a helical three-dimensional (3D) passive micromixer is presented. A three-dimensional spiral passive micromixer is fabricated through the 3D printing technology and the polymer dissolution technology. The main process is as follows: First of all, a high-impact polyst...

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Autores principales: Wang, Junyao, Chen, Xingyu, Liu, Huan, Li, Yunpeng, Lang, Tianhong, Wang, Rui, Cui, Bowen, Zhu, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756801/
https://www.ncbi.nlm.nih.gov/pubmed/35036815
http://dx.doi.org/10.1021/acsomega.1c06352
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author Wang, Junyao
Chen, Xingyu
Liu, Huan
Li, Yunpeng
Lang, Tianhong
Wang, Rui
Cui, Bowen
Zhu, Weihua
author_facet Wang, Junyao
Chen, Xingyu
Liu, Huan
Li, Yunpeng
Lang, Tianhong
Wang, Rui
Cui, Bowen
Zhu, Weihua
author_sort Wang, Junyao
collection PubMed
description [Image: see text] In this paper, a helical three-dimensional (3D) passive micromixer is presented. A three-dimensional spiral passive micromixer is fabricated through the 3D printing technology and the polymer dissolution technology. The main process is as follows: First of all, a high-impact polystyrene (HIPS) material was used to make a 3D spiral channel mold. Second, the channel mold was dissolved in limonene solvent. The mixing experiment shows that the single helix structure can improve the mixing efficiency to 0.85, compared with the mixing efficiency of 0.78 in the traditional T-shaped two-dimensional (2D)-plane channel. Different screw diameters, screw number structures, and flow rates are used to test the mixing effect. The optimal helical structure is 5 mm, and the flow rate is 2.0 mL/min. Finally, the mixing efficiency of the 3D helical micromixer can reach 0.948. The results show that the three-dimensional helical structure can effectively improve the mixing efficiency.
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spelling pubmed-87568012022-01-13 Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure Wang, Junyao Chen, Xingyu Liu, Huan Li, Yunpeng Lang, Tianhong Wang, Rui Cui, Bowen Zhu, Weihua ACS Omega [Image: see text] In this paper, a helical three-dimensional (3D) passive micromixer is presented. A three-dimensional spiral passive micromixer is fabricated through the 3D printing technology and the polymer dissolution technology. The main process is as follows: First of all, a high-impact polystyrene (HIPS) material was used to make a 3D spiral channel mold. Second, the channel mold was dissolved in limonene solvent. The mixing experiment shows that the single helix structure can improve the mixing efficiency to 0.85, compared with the mixing efficiency of 0.78 in the traditional T-shaped two-dimensional (2D)-plane channel. Different screw diameters, screw number structures, and flow rates are used to test the mixing effect. The optimal helical structure is 5 mm, and the flow rate is 2.0 mL/min. Finally, the mixing efficiency of the 3D helical micromixer can reach 0.948. The results show that the three-dimensional helical structure can effectively improve the mixing efficiency. American Chemical Society 2021-12-21 /pmc/articles/PMC8756801/ /pubmed/35036815 http://dx.doi.org/10.1021/acsomega.1c06352 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Junyao
Chen, Xingyu
Liu, Huan
Li, Yunpeng
Lang, Tianhong
Wang, Rui
Cui, Bowen
Zhu, Weihua
Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title_full Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title_fullStr Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title_full_unstemmed Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title_short Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure
title_sort efficient mixing of microfluidic chip with a three-dimensional spiral structure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756801/
https://www.ncbi.nlm.nih.gov/pubmed/35036815
http://dx.doi.org/10.1021/acsomega.1c06352
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