Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6

Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that promise the best chance of a successful trans...

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Detalles Bibliográficos
Autores principales: Lopez-Gordo, Estrella, Orlowski, Alejandro, Wang, Arthur, Weinberg, Alan, Sahoo, Susmita, Weber, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757481/
https://www.ncbi.nlm.nih.gov/pubmed/35036407
http://dx.doi.org/10.3389/fmed.2021.732095

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