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Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary sten...

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Autores principales: Milosevic, Miljan, Anic, Milos, Nikolic, Dalibor, Geroski, Vladimir, Milicevic, Bogdan, Kojic, Milos, Filipovic, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757700/
https://www.ncbi.nlm.nih.gov/pubmed/35047953
http://dx.doi.org/10.3389/fmedt.2021.724062
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author Milosevic, Miljan
Anic, Milos
Nikolic, Dalibor
Geroski, Vladimir
Milicevic, Bogdan
Kojic, Milos
Filipovic, Nenad
author_facet Milosevic, Miljan
Anic, Milos
Nikolic, Dalibor
Geroski, Vladimir
Milicevic, Bogdan
Kojic, Milos
Filipovic, Nenad
author_sort Milosevic, Miljan
collection PubMed
description Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. in silico mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform in silico mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents.
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spelling pubmed-87577002022-01-18 Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs Milosevic, Miljan Anic, Milos Nikolic, Dalibor Geroski, Vladimir Milicevic, Bogdan Kojic, Milos Filipovic, Nenad Front Med Technol Medical Technology Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. in silico mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform in silico mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8757700/ /pubmed/35047953 http://dx.doi.org/10.3389/fmedt.2021.724062 Text en Copyright © 2021 Milosevic, Anic, Nikolic, Geroski, Milicevic, Kojic and Filipovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Milosevic, Miljan
Anic, Milos
Nikolic, Dalibor
Geroski, Vladimir
Milicevic, Bogdan
Kojic, Milos
Filipovic, Nenad
Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title_full Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title_fullStr Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title_full_unstemmed Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title_short Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
title_sort application of in silico platform for the development and optimization of fully bioresorbable vascular scaffold designs
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757700/
https://www.ncbi.nlm.nih.gov/pubmed/35047953
http://dx.doi.org/10.3389/fmedt.2021.724062
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