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Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers
Oral squamous cell carcinoma (OSCC) includes tumors of the lips, tongue, gingivobuccal complex, and floor of the mouth. Prognosis for OSCC is highly heterogeneous, with overall 5-year survival of ~50%, but median survival of just 8–10 months for patients with locoregional recurrence or metastatic di...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757756/ https://www.ncbi.nlm.nih.gov/pubmed/35047983 http://dx.doi.org/10.3389/froh.2020.585710 |
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author | Chaudhary, Amrita Bag, Swarnendu Arora, Neeraj Radhakrishnan, Vivek S. Mishra, Deepak Mukherjee, Geetashree |
author_facet | Chaudhary, Amrita Bag, Swarnendu Arora, Neeraj Radhakrishnan, Vivek S. Mishra, Deepak Mukherjee, Geetashree |
author_sort | Chaudhary, Amrita |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) includes tumors of the lips, tongue, gingivobuccal complex, and floor of the mouth. Prognosis for OSCC is highly heterogeneous, with overall 5-year survival of ~50%, but median survival of just 8–10 months for patients with locoregional recurrence or metastatic disease. A key feature of OSCC is microenvironmental oxygen depletion due to rapid growth of constituent tumor cells, which triggers hypoxia-associated signaling events and metabolic adaptations that influence subsequent tumor progression. Better understanding of leukocyte responses to tissue hypoxia and onco-metabolite expression under low-oxygen conditions will therefore be essential to develop more effective methods of diagnosing and treating patients with OSCC. This review assesses recent literature on metabolic reprogramming, redox homeostasis, and associated signaling pathways that mediate crosstalk of OSCC with immune cells in the hypoxic tumor microenvironment. The likely functional consequences of this metabolic interface between oxygen-starved OSCC and infiltrating leukocytes are also discussed. The hypoxic microenvironment of OSCC modifies redox signaling and alters the metabolic profile of tumor-infiltrating immune cells. Improved understanding of heterotypic interactions between host leukocytes, tumor cells, and hypoxia-induced onco-metabolites will inform the development of novel theranostic strategies for OSCC. |
format | Online Article Text |
id | pubmed-8757756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87577562022-01-18 Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers Chaudhary, Amrita Bag, Swarnendu Arora, Neeraj Radhakrishnan, Vivek S. Mishra, Deepak Mukherjee, Geetashree Front Oral Health Oral Health Oral squamous cell carcinoma (OSCC) includes tumors of the lips, tongue, gingivobuccal complex, and floor of the mouth. Prognosis for OSCC is highly heterogeneous, with overall 5-year survival of ~50%, but median survival of just 8–10 months for patients with locoregional recurrence or metastatic disease. A key feature of OSCC is microenvironmental oxygen depletion due to rapid growth of constituent tumor cells, which triggers hypoxia-associated signaling events and metabolic adaptations that influence subsequent tumor progression. Better understanding of leukocyte responses to tissue hypoxia and onco-metabolite expression under low-oxygen conditions will therefore be essential to develop more effective methods of diagnosing and treating patients with OSCC. This review assesses recent literature on metabolic reprogramming, redox homeostasis, and associated signaling pathways that mediate crosstalk of OSCC with immune cells in the hypoxic tumor microenvironment. The likely functional consequences of this metabolic interface between oxygen-starved OSCC and infiltrating leukocytes are also discussed. The hypoxic microenvironment of OSCC modifies redox signaling and alters the metabolic profile of tumor-infiltrating immune cells. Improved understanding of heterotypic interactions between host leukocytes, tumor cells, and hypoxia-induced onco-metabolites will inform the development of novel theranostic strategies for OSCC. Frontiers Media S.A. 2020-12-16 /pmc/articles/PMC8757756/ /pubmed/35047983 http://dx.doi.org/10.3389/froh.2020.585710 Text en Copyright © 2020 Chaudhary, Bag, Arora, Radhakrishnan, Mishra and Mukherjee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oral Health Chaudhary, Amrita Bag, Swarnendu Arora, Neeraj Radhakrishnan, Vivek S. Mishra, Deepak Mukherjee, Geetashree Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title | Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title_full | Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title_fullStr | Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title_full_unstemmed | Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title_short | Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers |
title_sort | hypoxic transformation of immune cell metabolism within the microenvironment of oral cancers |
topic | Oral Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757756/ https://www.ncbi.nlm.nih.gov/pubmed/35047983 http://dx.doi.org/10.3389/froh.2020.585710 |
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