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Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission

Mother-to-child transmission of viruses and bacteria increases the risk of miscarriage and various diseases in children. Such transmissions can result in infections and diseases in infants or the induction of an inflammatory immune response through the placenta. Recently, we developed a silicon (Si)...

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Autores principales: Usui, Noriyoshi, Togawa, Shogo, Sumi, Takuya, Kobayashi, Yuki, Koyama, Yoshihisa, Nakamura, Yukiko, Kondo, Makoto, Shinoda, Koh, Kobayashi, Hikaru, Shimada, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757766/
https://www.ncbi.nlm.nih.gov/pubmed/35047922
http://dx.doi.org/10.3389/fmedt.2021.665506
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author Usui, Noriyoshi
Togawa, Shogo
Sumi, Takuya
Kobayashi, Yuki
Koyama, Yoshihisa
Nakamura, Yukiko
Kondo, Makoto
Shinoda, Koh
Kobayashi, Hikaru
Shimada, Shoichi
author_facet Usui, Noriyoshi
Togawa, Shogo
Sumi, Takuya
Kobayashi, Yuki
Koyama, Yoshihisa
Nakamura, Yukiko
Kondo, Makoto
Shinoda, Koh
Kobayashi, Hikaru
Shimada, Shoichi
author_sort Usui, Noriyoshi
collection PubMed
description Mother-to-child transmission of viruses and bacteria increases the risk of miscarriage and various diseases in children. Such transmissions can result in infections and diseases in infants or the induction of an inflammatory immune response through the placenta. Recently, we developed a silicon (Si)-based hydrogen-producing nanoagent (Si-based agent) that continuously and effectively produces hydrogen in the body. Since medical hydrogen has antioxidative, anti-inflammatory, antiallergic, and antiapoptotic effects, we investigated the effects of our Si-based agent on mother-to-child transmission, with a focus on the rate of miscarriage. In pregnant mice fed a diet containing the Si-based agent, lipopolysaccharide (LPS)-induced miscarriage due to mother-to-child transmission was reduced and inflammation and neutrophil infiltration in the placenta were suppressed. We also found that the Si-based agent suppressed IL-6 expression in the placenta and induced the expression of antioxidant and antiapoptotic genes, such as Hmox1 and Ptgs2. The observed anti-inflammatory effects of the Si-based agent suggest that it may be an effective preventative or therapeutic drug for miscarriage or threatened miscarriage during pregnancy by suppressing maternal inflammation caused by bacterial and viral infections.
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spelling pubmed-87577662022-01-18 Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission Usui, Noriyoshi Togawa, Shogo Sumi, Takuya Kobayashi, Yuki Koyama, Yoshihisa Nakamura, Yukiko Kondo, Makoto Shinoda, Koh Kobayashi, Hikaru Shimada, Shoichi Front Med Technol Medical Technology Mother-to-child transmission of viruses and bacteria increases the risk of miscarriage and various diseases in children. Such transmissions can result in infections and diseases in infants or the induction of an inflammatory immune response through the placenta. Recently, we developed a silicon (Si)-based hydrogen-producing nanoagent (Si-based agent) that continuously and effectively produces hydrogen in the body. Since medical hydrogen has antioxidative, anti-inflammatory, antiallergic, and antiapoptotic effects, we investigated the effects of our Si-based agent on mother-to-child transmission, with a focus on the rate of miscarriage. In pregnant mice fed a diet containing the Si-based agent, lipopolysaccharide (LPS)-induced miscarriage due to mother-to-child transmission was reduced and inflammation and neutrophil infiltration in the placenta were suppressed. We also found that the Si-based agent suppressed IL-6 expression in the placenta and induced the expression of antioxidant and antiapoptotic genes, such as Hmox1 and Ptgs2. The observed anti-inflammatory effects of the Si-based agent suggest that it may be an effective preventative or therapeutic drug for miscarriage or threatened miscarriage during pregnancy by suppressing maternal inflammation caused by bacterial and viral infections. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8757766/ /pubmed/35047922 http://dx.doi.org/10.3389/fmedt.2021.665506 Text en Copyright © 2021 Usui, Togawa, Sumi, Kobayashi, Koyama, Nakamura, Kondo, Shinoda, Kobayashi and Shimada. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Usui, Noriyoshi
Togawa, Shogo
Sumi, Takuya
Kobayashi, Yuki
Koyama, Yoshihisa
Nakamura, Yukiko
Kondo, Makoto
Shinoda, Koh
Kobayashi, Hikaru
Shimada, Shoichi
Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title_full Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title_fullStr Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title_full_unstemmed Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title_short Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
title_sort si-based hydrogen-producing nanoagent protects fetuses from miscarriage caused by mother-to-child transmission
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757766/
https://www.ncbi.nlm.nih.gov/pubmed/35047922
http://dx.doi.org/10.3389/fmedt.2021.665506
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