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Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data

Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in the occlusion of cerebral aneurysms after treatment. Objective: Verification and Validation of computational models in terms of predictive capacity, relating FD porosity and occlusion after cerebral aneurysms treatment....

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Autores principales: Narata, Ana Paula, Obradó, Laura, Moyano, Raquel Kalé, Macho, Juan M., Blasco, Jordi, Rueda, Antonio López, Roman, Luis San, Remollo, Sebastian, Marinelli, Claudia, Cepeda, Rosana, Fernández, Héctor, Larrabide, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757794/
https://www.ncbi.nlm.nih.gov/pubmed/35047944
http://dx.doi.org/10.3389/fmedt.2021.705003
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author Narata, Ana Paula
Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
author_facet Narata, Ana Paula
Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
author_sort Narata, Ana Paula
collection PubMed
description Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in the occlusion of cerebral aneurysms after treatment. Objective: Verification and Validation of computational models in terms of predictive capacity, relating FD porosity and occlusion after cerebral aneurysms treatment. Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, were considered. Patient demographics and aneurysm morphological information were collected. The computational simulation provided by ANKYRAS provided FD porosity, expansion, and mesh angle. FD occlusion was assessed and recorded from follow-up images. Multiple regression Logit and analysis of covariance (ANCOVA) models were used to model the data with both categorical and continuous models. Results: Occlusion of the aneurysm after 12 months was affected by aneurysm morphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 months on average was observed with an SE of 0.24 months in the aneurysm population surveyed. TTO was estimated with statistical significance from the resulting model for the data examined and was capable of explaining 92% of the data variation. Conclusions: Porosity was found to have the most correction power when assessing TTO, proving its importance in the process of aneurysm occlusion. Still, further Verification and Validation (V&V) of treatment simulation in more extensive, multi-center, and randomized databases is required.
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spelling pubmed-87577942022-01-18 Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data Narata, Ana Paula Obradó, Laura Moyano, Raquel Kalé Macho, Juan M. Blasco, Jordi Rueda, Antonio López Roman, Luis San Remollo, Sebastian Marinelli, Claudia Cepeda, Rosana Fernández, Héctor Larrabide, Ignacio Front Med Technol Medical Technology Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in the occlusion of cerebral aneurysms after treatment. Objective: Verification and Validation of computational models in terms of predictive capacity, relating FD porosity and occlusion after cerebral aneurysms treatment. Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, were considered. Patient demographics and aneurysm morphological information were collected. The computational simulation provided by ANKYRAS provided FD porosity, expansion, and mesh angle. FD occlusion was assessed and recorded from follow-up images. Multiple regression Logit and analysis of covariance (ANCOVA) models were used to model the data with both categorical and continuous models. Results: Occlusion of the aneurysm after 12 months was affected by aneurysm morphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 months on average was observed with an SE of 0.24 months in the aneurysm population surveyed. TTO was estimated with statistical significance from the resulting model for the data examined and was capable of explaining 92% of the data variation. Conclusions: Porosity was found to have the most correction power when assessing TTO, proving its importance in the process of aneurysm occlusion. Still, further Verification and Validation (V&V) of treatment simulation in more extensive, multi-center, and randomized databases is required. Frontiers Media S.A. 2021-09-17 /pmc/articles/PMC8757794/ /pubmed/35047944 http://dx.doi.org/10.3389/fmedt.2021.705003 Text en Copyright © 2021 Narata, Obradó, Moyano, Macho, Blasco, Rueda, Roman, Remollo, Marinelli, Cepeda, Fernández and Larrabide. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Narata, Ana Paula
Obradó, Laura
Moyano, Raquel Kalé
Macho, Juan M.
Blasco, Jordi
Rueda, Antonio López
Roman, Luis San
Remollo, Sebastian
Marinelli, Claudia
Cepeda, Rosana
Fernández, Héctor
Larrabide, Ignacio
Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title_full Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title_fullStr Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title_full_unstemmed Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title_short Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data
title_sort cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for v&v with real-world data
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757794/
https://www.ncbi.nlm.nih.gov/pubmed/35047944
http://dx.doi.org/10.3389/fmedt.2021.705003
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