Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)

DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This re...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Celio Lopes, Malardo, Thiago, Tahyra, Aline Seiko Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Medical Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757890/
https://www.ncbi.nlm.nih.gov/pubmed/35047886
http://dx.doi.org/10.3389/fmedt.2020.603690
_version_ 1784632780246745088
author Silva, Celio Lopes
Malardo, Thiago
Tahyra, Aline Seiko Carvalho
author_facet Silva, Celio Lopes
Malardo, Thiago
Tahyra, Aline Seiko Carvalho
author_sort Silva, Celio Lopes
collection PubMed
description DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp65 gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp65 in the control of various conditions is also discussed.
format Online
Article
Text
id pubmed-8757890
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87578902022-01-18 Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65) Silva, Celio Lopes Malardo, Thiago Tahyra, Aline Seiko Carvalho Front Med Technol Medical Technology DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp65 gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp65 in the control of various conditions is also discussed. Frontiers Media S.A. 2020-12-15 /pmc/articles/PMC8757890/ /pubmed/35047886 http://dx.doi.org/10.3389/fmedt.2020.603690 Text en Copyright © 2020 Silva, Malardo and Tahyra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Silva, Celio Lopes
Malardo, Thiago
Tahyra, Aline Seiko Carvalho
Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title_full Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title_fullStr Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title_full_unstemmed Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title_short Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)
title_sort immunotherapeutic activities of a dna plasmid carrying the mycobacterial hsp65 gene (dnahsp65)
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757890/
https://www.ncbi.nlm.nih.gov/pubmed/35047886
http://dx.doi.org/10.3389/fmedt.2020.603690
work_keys_str_mv AT silvaceliolopes immunotherapeuticactivitiesofadnaplasmidcarryingthemycobacterialhsp65genednahsp65
AT malardothiago immunotherapeuticactivitiesofadnaplasmidcarryingthemycobacterialhsp65genednahsp65
AT tahyraalineseikocarvalho immunotherapeuticactivitiesofadnaplasmidcarryingthemycobacterialhsp65genednahsp65

Ejemplares similares