Cargando…
Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma
Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cell...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757898/ https://www.ncbi.nlm.nih.gov/pubmed/35047994 http://dx.doi.org/10.3389/froh.2021.638213 |
_version_ | 1784632782124744704 |
---|---|
author | Hano, Kimika Hatano, Kiichi Saigo, Chiemi Kito, Yusuke Shibata, Toshiyuki Takeuchi, Tamotsu |
author_facet | Hano, Kimika Hatano, Kiichi Saigo, Chiemi Kito, Yusuke Shibata, Toshiyuki Takeuchi, Tamotsu |
author_sort | Hano, Kimika |
collection | PubMed |
description | Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cells to ER stress-induced apoptosis. In the present study, we examined whether these two ER stress-related proteins, Clptm1L and TMEM207, could be prognostic markers in oral squamous cell carcinoma (OSCC). Immunohistochemical staining using specific antibodies to Clptm1L or TMEM207 revealed that 31 of 89 tissue specimens exhibited concomitant expression of Clptm1L and TMEM207 at the cancer invasion front. A Kaplan–Meier plot of the patient survival curve followed by a log-rank test revealed that the coexpression of Clptm1L and TMEM207 was significantly associated with poor outcome in patients with OSCC (P = 0.00252). Coexpression of Clptm1L and TMEM207 was closely related to lymph node metastasis (P=0.000574). Both univariate and multivariate analyses demonstrated that coexpression of Clptm1L and TMEM207 predicted the poor prognosis of the patients with OSCC. The present study indicated that the double positive Clptm1L and TMEM207 immunoreactivity was closely related to lymph node metastasis with prognostic value in patients with OSCC. |
format | Online Article Text |
id | pubmed-8757898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87578982022-01-18 Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma Hano, Kimika Hatano, Kiichi Saigo, Chiemi Kito, Yusuke Shibata, Toshiyuki Takeuchi, Tamotsu Front Oral Health Oral Health Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cells to ER stress-induced apoptosis. In the present study, we examined whether these two ER stress-related proteins, Clptm1L and TMEM207, could be prognostic markers in oral squamous cell carcinoma (OSCC). Immunohistochemical staining using specific antibodies to Clptm1L or TMEM207 revealed that 31 of 89 tissue specimens exhibited concomitant expression of Clptm1L and TMEM207 at the cancer invasion front. A Kaplan–Meier plot of the patient survival curve followed by a log-rank test revealed that the coexpression of Clptm1L and TMEM207 was significantly associated with poor outcome in patients with OSCC (P = 0.00252). Coexpression of Clptm1L and TMEM207 was closely related to lymph node metastasis (P=0.000574). Both univariate and multivariate analyses demonstrated that coexpression of Clptm1L and TMEM207 predicted the poor prognosis of the patients with OSCC. The present study indicated that the double positive Clptm1L and TMEM207 immunoreactivity was closely related to lymph node metastasis with prognostic value in patients with OSCC. Frontiers Media S.A. 2021-03-29 /pmc/articles/PMC8757898/ /pubmed/35047994 http://dx.doi.org/10.3389/froh.2021.638213 Text en Copyright © 2021 Hano, Hatano, Saigo, Kito, Shibata and Takeuchi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oral Health Hano, Kimika Hatano, Kiichi Saigo, Chiemi Kito, Yusuke Shibata, Toshiyuki Takeuchi, Tamotsu Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title_full | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title_fullStr | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title_full_unstemmed | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title_short | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
title_sort | combination of clptm1l and tmem207 expression as a robust prognostic marker in oral squamous cell carcinoma |
topic | Oral Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757898/ https://www.ncbi.nlm.nih.gov/pubmed/35047994 http://dx.doi.org/10.3389/froh.2021.638213 |
work_keys_str_mv | AT hanokimika combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma AT hatanokiichi combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma AT saigochiemi combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma AT kitoyusuke combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma AT shibatatoshiyuki combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma AT takeuchitamotsu combinationofclptm1landtmem207expressionasarobustprognosticmarkerinoralsquamouscellcarcinoma |