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The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein

The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer’s disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ-secretases in the ’amyloidogenic’ proteolytic pa...

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Detalles Bibliográficos
Autores principales:	Parkin, Edward T., Hammond, Jessica E., Owens, Lauren, Hodges, Matthew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757967/ https://www.ncbi.nlm.nih.gov/pubmed/35025874 http://dx.doi.org/10.1371/journal.pone.0255715

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