Advances and gaps in SARS-CoV-2 infection models

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates o...

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Autores principales: Muñoz-Fontela, César, Widerspick, Lina, Albrecht, Randy A., Beer, Martin, Carroll, Miles W., de Wit, Emmie, Diamond, Michael S., Dowling, William E., Funnell, Simon G. P., García-Sastre, Adolfo, Gerhards, Nora M., de Jong, Rineke, Munster, Vincent J., Neyts, Johan, Perlman, Stanley, Reed, Douglas S., Richt, Juergen A., Riveros-Balta, Ximena, Roy, Chad J., Salguero, Francisco J., Schotsaert, Michael, Schwartz, Lauren M., Seder, Robert A., Segalés, Joaquim, Vasan, Seshadri S., Henao-Restrepo, Ana María, Barouch, Dan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757994/
https://www.ncbi.nlm.nih.gov/pubmed/35025969
http://dx.doi.org/10.1371/journal.ppat.1010161
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author Muñoz-Fontela, César
Widerspick, Lina
Albrecht, Randy A.
Beer, Martin
Carroll, Miles W.
de Wit, Emmie
Diamond, Michael S.
Dowling, William E.
Funnell, Simon G. P.
García-Sastre, Adolfo
Gerhards, Nora M.
de Jong, Rineke
Munster, Vincent J.
Neyts, Johan
Perlman, Stanley
Reed, Douglas S.
Richt, Juergen A.
Riveros-Balta, Ximena
Roy, Chad J.
Salguero, Francisco J.
Schotsaert, Michael
Schwartz, Lauren M.
Seder, Robert A.
Segalés, Joaquim
Vasan, Seshadri S.
Henao-Restrepo, Ana María
Barouch, Dan H.
author_facet Muñoz-Fontela, César
Widerspick, Lina
Albrecht, Randy A.
Beer, Martin
Carroll, Miles W.
de Wit, Emmie
Diamond, Michael S.
Dowling, William E.
Funnell, Simon G. P.
García-Sastre, Adolfo
Gerhards, Nora M.
de Jong, Rineke
Munster, Vincent J.
Neyts, Johan
Perlman, Stanley
Reed, Douglas S.
Richt, Juergen A.
Riveros-Balta, Ximena
Roy, Chad J.
Salguero, Francisco J.
Schotsaert, Michael
Schwartz, Lauren M.
Seder, Robert A.
Segalés, Joaquim
Vasan, Seshadri S.
Henao-Restrepo, Ana María
Barouch, Dan H.
author_sort Muñoz-Fontela, César
collection PubMed
description The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.
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spelling pubmed-87579942022-01-14 Advances and gaps in SARS-CoV-2 infection models Muñoz-Fontela, César Widerspick, Lina Albrecht, Randy A. Beer, Martin Carroll, Miles W. de Wit, Emmie Diamond, Michael S. Dowling, William E. Funnell, Simon G. P. García-Sastre, Adolfo Gerhards, Nora M. de Jong, Rineke Munster, Vincent J. Neyts, Johan Perlman, Stanley Reed, Douglas S. Richt, Juergen A. Riveros-Balta, Ximena Roy, Chad J. Salguero, Francisco J. Schotsaert, Michael Schwartz, Lauren M. Seder, Robert A. Segalés, Joaquim Vasan, Seshadri S. Henao-Restrepo, Ana María Barouch, Dan H. PLoS Pathog Review The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age. Public Library of Science 2022-01-13 /pmc/articles/PMC8757994/ /pubmed/35025969 http://dx.doi.org/10.1371/journal.ppat.1010161 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Review
Muñoz-Fontela, César
Widerspick, Lina
Albrecht, Randy A.
Beer, Martin
Carroll, Miles W.
de Wit, Emmie
Diamond, Michael S.
Dowling, William E.
Funnell, Simon G. P.
García-Sastre, Adolfo
Gerhards, Nora M.
de Jong, Rineke
Munster, Vincent J.
Neyts, Johan
Perlman, Stanley
Reed, Douglas S.
Richt, Juergen A.
Riveros-Balta, Ximena
Roy, Chad J.
Salguero, Francisco J.
Schotsaert, Michael
Schwartz, Lauren M.
Seder, Robert A.
Segalés, Joaquim
Vasan, Seshadri S.
Henao-Restrepo, Ana María
Barouch, Dan H.
Advances and gaps in SARS-CoV-2 infection models
title Advances and gaps in SARS-CoV-2 infection models
title_full Advances and gaps in SARS-CoV-2 infection models
title_fullStr Advances and gaps in SARS-CoV-2 infection models
title_full_unstemmed Advances and gaps in SARS-CoV-2 infection models
title_short Advances and gaps in SARS-CoV-2 infection models
title_sort advances and gaps in sars-cov-2 infection models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757994/
https://www.ncbi.nlm.nih.gov/pubmed/35025969
http://dx.doi.org/10.1371/journal.ppat.1010161
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