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Discontinuation of methotrexate in rheumatoid arthritis patients achieving clinical remission by treatment with upadacitinib plus methotrexate (DOPPLER study): A study protocol for an interventional, multicenter, open-label and single-arm clinical trial with clinical, ultrasound and biomarker assessments

BACKGROUND: The administration of Janus kinase inhibitors as well as biological disease-modifying anti-rheumatic drugs has dramatically improved the clinical outcomes of patients with rheumatoid arthritis (RA). Previous trials have shown that upadacitinib, a Janus kinase inhibitor, can effectively i...

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Detalles Bibliográficos
Autores principales:	Shimizu, Toshimasa, Kawashiri, Shin-ya, Sato, Shuntaro, Kawazoe, Yurika, Kuroda, Shohei, Kawasaki, Rina, Ito, Yasuko, Morimoto, Shimpei, Yamamoto, Hiroshi, Kawakami, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	6900
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758021/ https://www.ncbi.nlm.nih.gov/pubmed/35029189 http://dx.doi.org/10.1097/MD.0000000000028463

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