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Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report
RATIONALE: Multiple evanescent white dot syndrome (MEWDS) is an acute, usually unilateral, retinal disorder of unknown etiology that predominantly occurs in healthy young women. We report a case of bilateral asymmetric MEWDS that developed following the first vaccination for coronavirus-19 and worse...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758041/ https://www.ncbi.nlm.nih.gov/pubmed/35029236 http://dx.doi.org/10.1097/MD.0000000000028582 |
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author | Inagawa, Sayako Onda, Masahiro Miyase, Taishi Murase, Shiho Murase, Hiroki Mochizuki, Kiyofumi Sakaguchi, Hirokazu |
author_facet | Inagawa, Sayako Onda, Masahiro Miyase, Taishi Murase, Shiho Murase, Hiroki Mochizuki, Kiyofumi Sakaguchi, Hirokazu |
author_sort | Inagawa, Sayako |
collection | PubMed |
description | RATIONALE: Multiple evanescent white dot syndrome (MEWDS) is an acute, usually unilateral, retinal disorder of unknown etiology that predominantly occurs in healthy young women. We report a case of bilateral asymmetric MEWDS that developed following the first vaccination for coronavirus-19 and worsened after a second vaccination. PATIENT CONCERNS: A 30-year-old Japanese woman was examined in an eye clinic for blurred vision in her left eye for 1 week duration. Thirteen days before her examination, she had received her first BNT162b2 mRNA SARS-CoV-2 vaccination. Her best-corrected visual acuity was 20/20 in both eyes. Fundus examination revealed multiple yellowish-white spots in the perifoveal area of both eyes. Visibility of the spots gradually decreased during the following week. She was then vaccinated with a second dose, and 3 days later, her vision worsened in her left eye. She was then referred to our hospital because of worsened vision and the appearance of white spots on other parts of the retina. Ophthalmological examination revealed a best-corrected visual acuity of 30/20 both eyes. DIAGNOSIS: The flare value in the anterior chamber was elevated in both the eyes. Fundus examination showed multiple white spots in the perifoveal area of both eyes, but they were more prominent in the left eye. Fundus fluorescein angiography revealed early hyperfluorescent spots located circumferentially around the fovea in both eyes. We concluded that the patient had MEWDS, which was most likely due to mRNA COVID-19 immunization. INTERVENTIONS: The patient was treated with topical betamethasone sodium phosphate/fradiomycin sulfate 0.1% thrice daily for 2 months. OUTCOMES: Two months after treatment, her blurry vision resolved with the disappearance of the fundus lesions. LESSON: Clinicians should be aware of potential adverse ocular events following similar vaccinations. |
format | Online Article Text |
id | pubmed-8758041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-87580412022-01-19 Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report Inagawa, Sayako Onda, Masahiro Miyase, Taishi Murase, Shiho Murase, Hiroki Mochizuki, Kiyofumi Sakaguchi, Hirokazu Medicine (Baltimore) 4900 RATIONALE: Multiple evanescent white dot syndrome (MEWDS) is an acute, usually unilateral, retinal disorder of unknown etiology that predominantly occurs in healthy young women. We report a case of bilateral asymmetric MEWDS that developed following the first vaccination for coronavirus-19 and worsened after a second vaccination. PATIENT CONCERNS: A 30-year-old Japanese woman was examined in an eye clinic for blurred vision in her left eye for 1 week duration. Thirteen days before her examination, she had received her first BNT162b2 mRNA SARS-CoV-2 vaccination. Her best-corrected visual acuity was 20/20 in both eyes. Fundus examination revealed multiple yellowish-white spots in the perifoveal area of both eyes. Visibility of the spots gradually decreased during the following week. She was then vaccinated with a second dose, and 3 days later, her vision worsened in her left eye. She was then referred to our hospital because of worsened vision and the appearance of white spots on other parts of the retina. Ophthalmological examination revealed a best-corrected visual acuity of 30/20 both eyes. DIAGNOSIS: The flare value in the anterior chamber was elevated in both the eyes. Fundus examination showed multiple white spots in the perifoveal area of both eyes, but they were more prominent in the left eye. Fundus fluorescein angiography revealed early hyperfluorescent spots located circumferentially around the fovea in both eyes. We concluded that the patient had MEWDS, which was most likely due to mRNA COVID-19 immunization. INTERVENTIONS: The patient was treated with topical betamethasone sodium phosphate/fradiomycin sulfate 0.1% thrice daily for 2 months. OUTCOMES: Two months after treatment, her blurry vision resolved with the disappearance of the fundus lesions. LESSON: Clinicians should be aware of potential adverse ocular events following similar vaccinations. Lippincott Williams & Wilkins 2022-01-14 /pmc/articles/PMC8758041/ /pubmed/35029236 http://dx.doi.org/10.1097/MD.0000000000028582 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | 4900 Inagawa, Sayako Onda, Masahiro Miyase, Taishi Murase, Shiho Murase, Hiroki Mochizuki, Kiyofumi Sakaguchi, Hirokazu Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title | Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title_full | Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title_fullStr | Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title_full_unstemmed | Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title_short | Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report |
title_sort | multiple evanescent white dot syndrome following vaccination for covid-19: a case report |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758041/ https://www.ncbi.nlm.nih.gov/pubmed/35029236 http://dx.doi.org/10.1097/MD.0000000000028582 |
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