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Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations
BACKGROUND: In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis. METHODS: Prospective study of 60 outpatients on chroni...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758069/ https://www.ncbi.nlm.nih.gov/pubmed/35025892 http://dx.doi.org/10.1371/journal.pone.0261459 |
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author | Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca Gracia-Iguacel, Carolina de-Alba-Peñaranda, Ana María Mas-Fontao, Sebastian López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Ortíz, Alberto González-Parra, Emilio |
author_facet | Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca Gracia-Iguacel, Carolina de-Alba-Peñaranda, Ana María Mas-Fontao, Sebastian López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Ortíz, Alberto González-Parra, Emilio |
author_sort | Sánchez-Tocino, M. Luz |
collection | PubMed |
description | BACKGROUND: In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis. METHODS: Prospective study of 60 outpatients on chronic hemodialysis aged 75- to 95-years, sarcopenia was assessed according to the 4-step EWGSOP2: Find: Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F); Assess: grip strength by dynamometry (GSD) and sit to stand to sit 5 (STS5); Confirm: appendicular skeletal muscle mass (ASM) by bioimpedance; Severity: gait speed (GS), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB). RESULTS: The sequential four steps resulted in a prevalence of confirmed or severe sarcopenia of 20%. Most (97%) patients fulfilled at least one criterion for probable sarcopenia. The sensitivity of SARC-F for confirmed sarcopenia was low (46%). Skipping the SARC-F step increased the prevalence of confirmed and severe sarcopenia to 40% and 37%, respectively. However, 78% of all patients had evidence of dynapenia consistent with severe sarcopenia. Muscle mass (ASM) was normal in 60% of patients, while only 25% had normal muscle strength values (GSD). CONCLUSIONS: According to the 4-step EWGSOP2, the prevalence of confirmed or severe sarcopenia was low in elderly hemodialysis patients. The diagnosis of confirmed sarcopenia underestimated the prevalence of dynapenia consistent with severe sarcopenia. Future studies should address whether a 2-step EWGSOP2 assessment (Assess-Severity) is simpler to apply and may provide better prognostic information than 4-step EWGSOP2 in elderly persons on hemodialysis. |
format | Online Article Text |
id | pubmed-8758069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-87580692022-01-14 Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca Gracia-Iguacel, Carolina de-Alba-Peñaranda, Ana María Mas-Fontao, Sebastian López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Ortíz, Alberto González-Parra, Emilio PLoS One Research Article BACKGROUND: In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis. METHODS: Prospective study of 60 outpatients on chronic hemodialysis aged 75- to 95-years, sarcopenia was assessed according to the 4-step EWGSOP2: Find: Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F); Assess: grip strength by dynamometry (GSD) and sit to stand to sit 5 (STS5); Confirm: appendicular skeletal muscle mass (ASM) by bioimpedance; Severity: gait speed (GS), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB). RESULTS: The sequential four steps resulted in a prevalence of confirmed or severe sarcopenia of 20%. Most (97%) patients fulfilled at least one criterion for probable sarcopenia. The sensitivity of SARC-F for confirmed sarcopenia was low (46%). Skipping the SARC-F step increased the prevalence of confirmed and severe sarcopenia to 40% and 37%, respectively. However, 78% of all patients had evidence of dynapenia consistent with severe sarcopenia. Muscle mass (ASM) was normal in 60% of patients, while only 25% had normal muscle strength values (GSD). CONCLUSIONS: According to the 4-step EWGSOP2, the prevalence of confirmed or severe sarcopenia was low in elderly hemodialysis patients. The diagnosis of confirmed sarcopenia underestimated the prevalence of dynapenia consistent with severe sarcopenia. Future studies should address whether a 2-step EWGSOP2 assessment (Assess-Severity) is simpler to apply and may provide better prognostic information than 4-step EWGSOP2 in elderly persons on hemodialysis. Public Library of Science 2022-01-13 /pmc/articles/PMC8758069/ /pubmed/35025892 http://dx.doi.org/10.1371/journal.pone.0261459 Text en © 2022 Sánchez-Tocino et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca Gracia-Iguacel, Carolina de-Alba-Peñaranda, Ana María Mas-Fontao, Sebastian López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Ortíz, Alberto González-Parra, Emilio Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title | Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title_full | Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title_fullStr | Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title_full_unstemmed | Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title_short | Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations |
title_sort | sarcopenia assessed by 4-step ewgsop2 in elderly hemodialysis patients: feasibility and limitations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758069/ https://www.ncbi.nlm.nih.gov/pubmed/35025892 http://dx.doi.org/10.1371/journal.pone.0261459 |
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