Cargando…

Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm

Emotionally charged distracters delay timing behavior. Increasing catecholamine levels within the prelimbic cortex has beneficial effects on timing by decreasing the delay after aversive distracters. We examined whether increasing catecholamine levels within the prelimbic cortex also protects agains...

Descripción completa

Detalles Bibliográficos
Autores principales: Matthews, Alexander R., Buhusi, Mona, Buhusi, Catalin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758100/
https://www.ncbi.nlm.nih.gov/pubmed/35036990
http://dx.doi.org/10.3390/neurosci1020010
_version_ 1784632829585391616
author Matthews, Alexander R.
Buhusi, Mona
Buhusi, Catalin V.
author_facet Matthews, Alexander R.
Buhusi, Mona
Buhusi, Catalin V.
author_sort Matthews, Alexander R.
collection PubMed
description Emotionally charged distracters delay timing behavior. Increasing catecholamine levels within the prelimbic cortex has beneficial effects on timing by decreasing the delay after aversive distracters. We examined whether increasing catecholamine levels within the prelimbic cortex also protects against the deleterious timing delays caused by novel distracters or by familiar appetitive distracters. Rats were trained in a peak-interval procedure and tested in trials with either a novel (unreinforced) distracter, a familiar appetitive (food-reinforced) distracter, or no distracter after being locally infused within the prelimbic cortex with catecholamine reuptake blocker nomifensine. Prelimbic infusion of nomifensine did not alter timing accuracy and precision. However, it increased the delay caused by novel distracters in an inverted-U dose-dependent manner, while being ineffective for appetitive distracters. Together with previous data, these results suggest that catecholaminergic modulation of prelimbic top-down attentional control of interval timing varies with distracter’s valence: prelimbic catecholamines increase attentional control when presented with familiar aversive distracters, have no effect on familiar neutral or familiar appetitive distracters, and decrease it when presented with novel distracters. These findings detail complex interactions between catecholaminergic modulation of attention to timing and nontemporal properties of stimuli, which should be considered when developing therapeutic methods for attentional or affective disorders.
format Online
Article
Text
id pubmed-8758100
institution National Center for Biotechnology Information
language English
publishDate 2020
record_format MEDLINE/PubMed
spelling pubmed-87581002022-01-13 Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm Matthews, Alexander R. Buhusi, Mona Buhusi, Catalin V. NeuroSci Article Emotionally charged distracters delay timing behavior. Increasing catecholamine levels within the prelimbic cortex has beneficial effects on timing by decreasing the delay after aversive distracters. We examined whether increasing catecholamine levels within the prelimbic cortex also protects against the deleterious timing delays caused by novel distracters or by familiar appetitive distracters. Rats were trained in a peak-interval procedure and tested in trials with either a novel (unreinforced) distracter, a familiar appetitive (food-reinforced) distracter, or no distracter after being locally infused within the prelimbic cortex with catecholamine reuptake blocker nomifensine. Prelimbic infusion of nomifensine did not alter timing accuracy and precision. However, it increased the delay caused by novel distracters in an inverted-U dose-dependent manner, while being ineffective for appetitive distracters. Together with previous data, these results suggest that catecholaminergic modulation of prelimbic top-down attentional control of interval timing varies with distracter’s valence: prelimbic catecholamines increase attentional control when presented with familiar aversive distracters, have no effect on familiar neutral or familiar appetitive distracters, and decrease it when presented with novel distracters. These findings detail complex interactions between catecholaminergic modulation of attention to timing and nontemporal properties of stimuli, which should be considered when developing therapeutic methods for attentional or affective disorders. 2020-12 2020-12-08 /pmc/articles/PMC8758100/ /pubmed/35036990 http://dx.doi.org/10.3390/neurosci1020010 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Matthews, Alexander R.
Buhusi, Mona
Buhusi, Catalin V.
Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title_full Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title_fullStr Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title_full_unstemmed Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title_short Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm
title_sort blockade of catecholamine reuptake in the prelimbic cortex decreases top-down attentional control in response to novel, but not familiar appetitive distracters, within a timing paradigm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758100/
https://www.ncbi.nlm.nih.gov/pubmed/35036990
http://dx.doi.org/10.3390/neurosci1020010
work_keys_str_mv AT matthewsalexanderr blockadeofcatecholaminereuptakeintheprelimbiccortexdecreasestopdownattentionalcontrolinresponsetonovelbutnotfamiliarappetitivedistracterswithinatimingparadigm
AT buhusimona blockadeofcatecholaminereuptakeintheprelimbiccortexdecreasestopdownattentionalcontrolinresponsetonovelbutnotfamiliarappetitivedistracterswithinatimingparadigm
AT buhusicatalinv blockadeofcatecholaminereuptakeintheprelimbiccortexdecreasestopdownattentionalcontrolinresponsetonovelbutnotfamiliarappetitivedistracterswithinatimingparadigm