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Association of mitochondrial DNA copy number with cardiometabolic diseases
Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold associat...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758111/ https://www.ncbi.nlm.nih.gov/pubmed/35036986 http://dx.doi.org/10.1016/j.xgen.2021.100006 |
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| author | Liu, Xue Longchamps, Ryan J. Wiggins, Kerri L. Raffield, Laura M. Bielak, Lawrence F. Zhao, Wei Pitsillides, Achilleas Blackwell, Thomas W. Yao, Jie Guo, Xiuqing Kurniansyah, Nuzulul Thyagarajan, Bharat Pankratz, Nathan Rich, Stephen S. Taylor, Kent D. Peyser, Patricia A. Heckbert, Susan R. Seshadri, Sudha Cupples, L. Adrienne Boerwinkle, Eric Grove, Megan L. Larson, Nicholas B. Smith, Jennifer A. Vasan, Ramachandran S. Sofer, Tamar Fitzpatrick, Annette L. Fornage, Myriam Ding, Jun Correa, Adolfo Abecasis, Goncalo Psaty, Bruce M. Wilson, James G. Levy, Daniel Rotter, Jerome I. Bis, Joshua C. Satizabal, Claudia L. Arking, Dan E. Liu, Chunyu |
| author_facet | Liu, Xue Longchamps, Ryan J. Wiggins, Kerri L. Raffield, Laura M. Bielak, Lawrence F. Zhao, Wei Pitsillides, Achilleas Blackwell, Thomas W. Yao, Jie Guo, Xiuqing Kurniansyah, Nuzulul Thyagarajan, Bharat Pankratz, Nathan Rich, Stephen S. Taylor, Kent D. Peyser, Patricia A. Heckbert, Susan R. Seshadri, Sudha Cupples, L. Adrienne Boerwinkle, Eric Grove, Megan L. Larson, Nicholas B. Smith, Jennifer A. Vasan, Ramachandran S. Sofer, Tamar Fitzpatrick, Annette L. Fornage, Myriam Ding, Jun Correa, Adolfo Abecasis, Goncalo Psaty, Bruce M. Wilson, James G. Levy, Daniel Rotter, Jerome I. Bis, Joshua C. Satizabal, Claudia L. Arking, Dan E. Liu, Chunyu |
| author_sort | Liu, Xue |
| collection | PubMed |
| description | Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: each additional 10 years of age was associated with a 0.03 SD higher level of mtDNA CN (p = 0.0014) among younger participants (younger than 65 years) versus a 0.14 SD lower level of mtDNA CN (p = 1.82 × 10(−13)) among older participants (65 years and older). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity (p = 5.6 × 10(−238)), hypertension (p = 2.8 × 10(−50)), diabetes (p = 3.6 × 10(−7)), and hyperlipidemia (p = 6.3 × 10(−5)(6)). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases. |
| format | Online Article Text |
| id | pubmed-8758111 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87581112022-01-13 Association of mitochondrial DNA copy number with cardiometabolic diseases Liu, Xue Longchamps, Ryan J. Wiggins, Kerri L. Raffield, Laura M. Bielak, Lawrence F. Zhao, Wei Pitsillides, Achilleas Blackwell, Thomas W. Yao, Jie Guo, Xiuqing Kurniansyah, Nuzulul Thyagarajan, Bharat Pankratz, Nathan Rich, Stephen S. Taylor, Kent D. Peyser, Patricia A. Heckbert, Susan R. Seshadri, Sudha Cupples, L. Adrienne Boerwinkle, Eric Grove, Megan L. Larson, Nicholas B. Smith, Jennifer A. Vasan, Ramachandran S. Sofer, Tamar Fitzpatrick, Annette L. Fornage, Myriam Ding, Jun Correa, Adolfo Abecasis, Goncalo Psaty, Bruce M. Wilson, James G. Levy, Daniel Rotter, Jerome I. Bis, Joshua C. Satizabal, Claudia L. Arking, Dan E. Liu, Chunyu Cell Genom Article Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: each additional 10 years of age was associated with a 0.03 SD higher level of mtDNA CN (p = 0.0014) among younger participants (younger than 65 years) versus a 0.14 SD lower level of mtDNA CN (p = 1.82 × 10(−13)) among older participants (65 years and older). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity (p = 5.6 × 10(−238)), hypertension (p = 2.8 × 10(−50)), diabetes (p = 3.6 × 10(−7)), and hyperlipidemia (p = 6.3 × 10(−5)(6)). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases. Elsevier 2021-10-13 /pmc/articles/PMC8758111/ /pubmed/35036986 http://dx.doi.org/10.1016/j.xgen.2021.100006 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Liu, Xue Longchamps, Ryan J. Wiggins, Kerri L. Raffield, Laura M. Bielak, Lawrence F. Zhao, Wei Pitsillides, Achilleas Blackwell, Thomas W. Yao, Jie Guo, Xiuqing Kurniansyah, Nuzulul Thyagarajan, Bharat Pankratz, Nathan Rich, Stephen S. Taylor, Kent D. Peyser, Patricia A. Heckbert, Susan R. Seshadri, Sudha Cupples, L. Adrienne Boerwinkle, Eric Grove, Megan L. Larson, Nicholas B. Smith, Jennifer A. Vasan, Ramachandran S. Sofer, Tamar Fitzpatrick, Annette L. Fornage, Myriam Ding, Jun Correa, Adolfo Abecasis, Goncalo Psaty, Bruce M. Wilson, James G. Levy, Daniel Rotter, Jerome I. Bis, Joshua C. Satizabal, Claudia L. Arking, Dan E. Liu, Chunyu Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title_full | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title_fullStr | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title_full_unstemmed | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title_short | Association of mitochondrial DNA copy number with cardiometabolic diseases |
| title_sort | association of mitochondrial dna copy number with cardiometabolic diseases |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758111/ https://www.ncbi.nlm.nih.gov/pubmed/35036986 http://dx.doi.org/10.1016/j.xgen.2021.100006 |
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