Association of mitochondrial DNA copy number with cardiometabolic diseases

Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold associat...

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Detalles Bibliográficos
Autores principales: Liu, Xue, Longchamps, Ryan J., Wiggins, Kerri L., Raffield, Laura M., Bielak, Lawrence F., Zhao, Wei, Pitsillides, Achilleas, Blackwell, Thomas W., Yao, Jie, Guo, Xiuqing, Kurniansyah, Nuzulul, Thyagarajan, Bharat, Pankratz, Nathan, Rich, Stephen S., Taylor, Kent D., Peyser, Patricia A., Heckbert, Susan R., Seshadri, Sudha, Cupples, L. Adrienne, Boerwinkle, Eric, Grove, Megan L., Larson, Nicholas B., Smith, Jennifer A., Vasan, Ramachandran S., Sofer, Tamar, Fitzpatrick, Annette L., Fornage, Myriam, Ding, Jun, Correa, Adolfo, Abecasis, Goncalo, Psaty, Bruce M., Wilson, James G., Levy, Daniel, Rotter, Jerome I., Bis, Joshua C., Satizabal, Claudia L., Arking, Dan E., Liu, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758111/
https://www.ncbi.nlm.nih.gov/pubmed/35036986
http://dx.doi.org/10.1016/j.xgen.2021.100006

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