Cargando…

Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahriari-Felordi, Mahtab, Alikhani, Hani Keshavarz, Hashemian, Seyed-Mohammad Reza, Hassan, Moustapha, Vosough, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758217/
https://www.ncbi.nlm.nih.gov/pubmed/35028855
http://dx.doi.org/10.1007/s11033-021-07071-9
_version_ 1784632849262968832
author Shahriari-Felordi, Mahtab
Alikhani, Hani Keshavarz
Hashemian, Seyed-Mohammad Reza
Hassan, Moustapha
Vosough, Massoud
author_facet Shahriari-Felordi, Mahtab
Alikhani, Hani Keshavarz
Hashemian, Seyed-Mohammad Reza
Hassan, Moustapha
Vosough, Massoud
author_sort Shahriari-Felordi, Mahtab
collection PubMed
description Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed.
format Online
Article
Text
id pubmed-8758217
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-87582172022-01-14 Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients Shahriari-Felordi, Mahtab Alikhani, Hani Keshavarz Hashemian, Seyed-Mohammad Reza Hassan, Moustapha Vosough, Massoud Mol Biol Rep Mini Review Article Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed. Springer Netherlands 2022-01-14 2022 /pmc/articles/PMC8758217/ /pubmed/35028855 http://dx.doi.org/10.1007/s11033-021-07071-9 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mini Review Article
Shahriari-Felordi, Mahtab
Alikhani, Hani Keshavarz
Hashemian, Seyed-Mohammad Reza
Hassan, Moustapha
Vosough, Massoud
Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title_full Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title_fullStr Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title_full_unstemmed Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title_short Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
title_sort mini review atf4 and grp78 as novel molecular targets in er-stress modulation for critical covid-19 patients
topic Mini Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758217/
https://www.ncbi.nlm.nih.gov/pubmed/35028855
http://dx.doi.org/10.1007/s11033-021-07071-9
work_keys_str_mv AT shahriarifelordimahtab minireviewatf4andgrp78asnovelmoleculartargetsinerstressmodulationforcriticalcovid19patients
AT alikhanihanikeshavarz minireviewatf4andgrp78asnovelmoleculartargetsinerstressmodulationforcriticalcovid19patients
AT hashemianseyedmohammadreza minireviewatf4andgrp78asnovelmoleculartargetsinerstressmodulationforcriticalcovid19patients
AT hassanmoustapha minireviewatf4andgrp78asnovelmoleculartargetsinerstressmodulationforcriticalcovid19patients
AT vosoughmassoud minireviewatf4andgrp78asnovelmoleculartargetsinerstressmodulationforcriticalcovid19patients