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The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis
Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758293/ https://www.ncbi.nlm.nih.gov/pubmed/35036448 http://dx.doi.org/10.1155/2022/6764379 |
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author | Gong, Jiao Chen, Yaqiong Cao, Jing Wang, Yang Chen, Jiahao Li, Danyang Sha, Liuping Li, Xinhua Chong, Yutian Hu, Bo |
author_facet | Gong, Jiao Chen, Yaqiong Cao, Jing Wang, Yang Chen, Jiahao Li, Danyang Sha, Liuping Li, Xinhua Chong, Yutian Hu, Bo |
author_sort | Gong, Jiao |
collection | PubMed |
description | Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets, infiltrated immune cells were quantified by single-sample gene set enrichment analysis method. The expression levels of immune genes and the abundance of immune cells in liver failure were compared with those in normal liver. The enrichment scores of cell death gene sets from Kyoto Encyclopedia of Genes and Genomes (KEGG) were calculated by gene set variation analysis method, and a protein-protein interaction (PPI) network was constructed using Cytoscape. Besides 21 differentially expressed immune genes, we identified 11 types of differentially infiltrated immune cells in HBV-ALF compared with normal liver. Enriched pathways of these immune genes mainly consisted of chemokine receptors, chemokine binding, interleukin-10 signaling, and TNFs bind their physiological receptors by Reactome pathway analysis. In addition, the enrichment scores of apoptosis and necroptosis pathway instead of autophagy and ferroptosis were increased in liver failure compared with normal liver. PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis. |
format | Online Article Text |
id | pubmed-8758293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87582932022-01-14 The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis Gong, Jiao Chen, Yaqiong Cao, Jing Wang, Yang Chen, Jiahao Li, Danyang Sha, Liuping Li, Xinhua Chong, Yutian Hu, Bo J Immunol Res Research Article Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets, infiltrated immune cells were quantified by single-sample gene set enrichment analysis method. The expression levels of immune genes and the abundance of immune cells in liver failure were compared with those in normal liver. The enrichment scores of cell death gene sets from Kyoto Encyclopedia of Genes and Genomes (KEGG) were calculated by gene set variation analysis method, and a protein-protein interaction (PPI) network was constructed using Cytoscape. Besides 21 differentially expressed immune genes, we identified 11 types of differentially infiltrated immune cells in HBV-ALF compared with normal liver. Enriched pathways of these immune genes mainly consisted of chemokine receptors, chemokine binding, interleukin-10 signaling, and TNFs bind their physiological receptors by Reactome pathway analysis. In addition, the enrichment scores of apoptosis and necroptosis pathway instead of autophagy and ferroptosis were increased in liver failure compared with normal liver. PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis. Hindawi 2022-01-06 /pmc/articles/PMC8758293/ /pubmed/35036448 http://dx.doi.org/10.1155/2022/6764379 Text en Copyright © 2022 Jiao Gong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gong, Jiao Chen, Yaqiong Cao, Jing Wang, Yang Chen, Jiahao Li, Danyang Sha, Liuping Li, Xinhua Chong, Yutian Hu, Bo The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title_full | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title_fullStr | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title_full_unstemmed | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title_short | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
title_sort | immune landscape of hepatitis b virus-related acute liver failure by integration analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758293/ https://www.ncbi.nlm.nih.gov/pubmed/35036448 http://dx.doi.org/10.1155/2022/6764379 |
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