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Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-κB pathway participated in anti-inflammation of sesamol in SCI...

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Autores principales: Feng, Xiaochu, Chen, Xianghang, Zaeem, Muhammad, Zhang, Wanying, Song, Liwan, Chen, Lulu, Mubwandarikwa, Joana, Chen, Xiangxiang, Xiao, Jian, Xie, Ling, Ye, Keyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758308/
https://www.ncbi.nlm.nih.gov/pubmed/35035666
http://dx.doi.org/10.1155/2022/8010670
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author Feng, Xiaochu
Chen, Xianghang
Zaeem, Muhammad
Zhang, Wanying
Song, Liwan
Chen, Lulu
Mubwandarikwa, Joana
Chen, Xiangxiang
Xiao, Jian
Xie, Ling
Ye, Keyong
author_facet Feng, Xiaochu
Chen, Xianghang
Zaeem, Muhammad
Zhang, Wanying
Song, Liwan
Chen, Lulu
Mubwandarikwa, Joana
Chen, Xiangxiang
Xiao, Jian
Xie, Ling
Ye, Keyong
author_sort Feng, Xiaochu
collection PubMed
description Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-κB pathway participated in anti-inflammation of sesamol in SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery in mice after SCI. Furthermore, sesamol increased SIRT1 protein expression and p-AMPK/AMPK ratio, while it downregulated the p-p65/p65 ratio, indicating that sesamol treatment upregulated the AMPK/SIRT1 pathway and inhibited NF-κB activation. However, these effects were blocked by compound C which is a specific AMPK inhibitor. Together, the study suggests that sesamol is a potential drug for antineuroinflammation and improving locomotor functional recovery through regulation of the AMPK/SIRT1/NF-κB pathway in SCI.
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spelling pubmed-87583082022-01-14 Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice Feng, Xiaochu Chen, Xianghang Zaeem, Muhammad Zhang, Wanying Song, Liwan Chen, Lulu Mubwandarikwa, Joana Chen, Xiangxiang Xiao, Jian Xie, Ling Ye, Keyong Oxid Med Cell Longev Research Article Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-κB pathway participated in anti-inflammation of sesamol in SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery in mice after SCI. Furthermore, sesamol increased SIRT1 protein expression and p-AMPK/AMPK ratio, while it downregulated the p-p65/p65 ratio, indicating that sesamol treatment upregulated the AMPK/SIRT1 pathway and inhibited NF-κB activation. However, these effects were blocked by compound C which is a specific AMPK inhibitor. Together, the study suggests that sesamol is a potential drug for antineuroinflammation and improving locomotor functional recovery through regulation of the AMPK/SIRT1/NF-κB pathway in SCI. Hindawi 2022-01-06 /pmc/articles/PMC8758308/ /pubmed/35035666 http://dx.doi.org/10.1155/2022/8010670 Text en Copyright © 2022 Xiaochu Feng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Xiaochu
Chen, Xianghang
Zaeem, Muhammad
Zhang, Wanying
Song, Liwan
Chen, Lulu
Mubwandarikwa, Joana
Chen, Xiangxiang
Xiao, Jian
Xie, Ling
Ye, Keyong
Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title_full Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title_fullStr Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title_full_unstemmed Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title_short Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
title_sort sesamol attenuates neuroinflammation by regulating the ampk/sirt1/nf-κb signaling pathway after spinal cord injury in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758308/
https://www.ncbi.nlm.nih.gov/pubmed/35035666
http://dx.doi.org/10.1155/2022/8010670
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