Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature

Paraneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disor...

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Autores principales: Nakashima, Koki, Demura, Yoshiki, Kurokawa, Kosuke, Takeda, Toshihiro, Jikuya, Norihiro, Oi, Masahiro, Tada, Toshihiko, Akai, Masaya, Ishizuka, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758326/
https://www.ncbi.nlm.nih.gov/pubmed/35036012
http://dx.doi.org/10.1155/2022/9290922
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author Nakashima, Koki
Demura, Yoshiki
Kurokawa, Kosuke
Takeda, Toshihiro
Jikuya, Norihiro
Oi, Masahiro
Tada, Toshihiko
Akai, Masaya
Ishizuka, Tamotsu
author_facet Nakashima, Koki
Demura, Yoshiki
Kurokawa, Kosuke
Takeda, Toshihiro
Jikuya, Norihiro
Oi, Masahiro
Tada, Toshihiko
Akai, Masaya
Ishizuka, Tamotsu
author_sort Nakashima, Koki
collection PubMed
description Paraneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disorientation, dysphagia, and gait disturbance after three courses of treatment with atezolizumab. Brain magnetic resonance imaging revealed a high-intensity area in the bilateral temporal lobes. Blood test results were positive for anti-Hu and anti-Zic4 antibodies, which led to the diagnosis of limbic encephalitis as PNS. Some symptoms improved with intravenous administration of steroids and immunoglobulins.
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spelling pubmed-87583262022-01-14 Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature Nakashima, Koki Demura, Yoshiki Kurokawa, Kosuke Takeda, Toshihiro Jikuya, Norihiro Oi, Masahiro Tada, Toshihiko Akai, Masaya Ishizuka, Tamotsu Case Reports Immunol Case Report Paraneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disorientation, dysphagia, and gait disturbance after three courses of treatment with atezolizumab. Brain magnetic resonance imaging revealed a high-intensity area in the bilateral temporal lobes. Blood test results were positive for anti-Hu and anti-Zic4 antibodies, which led to the diagnosis of limbic encephalitis as PNS. Some symptoms improved with intravenous administration of steroids and immunoglobulins. Hindawi 2022-01-06 /pmc/articles/PMC8758326/ /pubmed/35036012 http://dx.doi.org/10.1155/2022/9290922 Text en Copyright © 2022 Koki Nakashima et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nakashima, Koki
Demura, Yoshiki
Kurokawa, Kosuke
Takeda, Toshihiro
Jikuya, Norihiro
Oi, Masahiro
Tada, Toshihiko
Akai, Masaya
Ishizuka, Tamotsu
Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title_full Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title_fullStr Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title_full_unstemmed Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title_short Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
title_sort immune checkpoint inhibitor-induced limbic encephalitis during treatment with atezolizumab in a patient with small-cell lung cancer: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758326/
https://www.ncbi.nlm.nih.gov/pubmed/35036012
http://dx.doi.org/10.1155/2022/9290922
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