Omicron’s message on vaccines: Boosting begets breadth

In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense—neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in...

Descripción completa

Detalles Bibliográficos
Autor principal: Wesemann, Duane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758338/
https://www.ncbi.nlm.nih.gov/pubmed/35065712
http://dx.doi.org/10.1016/j.cell.2022.01.006
_version_ 1784632877008289792
author Wesemann, Duane R.
author_facet Wesemann, Duane R.
author_sort Wesemann, Duane R.
collection PubMed
description In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense—neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in a way that highlights the adaptability of immune memory, where recalled immunity extends antibody reach across SARS-CoV-2 variants.
format Online
Article
Text
id pubmed-8758338
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-87583382022-01-14 Omicron’s message on vaccines: Boosting begets breadth Wesemann, Duane R. Cell Preview In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense—neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in a way that highlights the adaptability of immune memory, where recalled immunity extends antibody reach across SARS-CoV-2 variants. Elsevier Inc. 2022-02-03 2022-01-14 /pmc/articles/PMC8758338/ /pubmed/35065712 http://dx.doi.org/10.1016/j.cell.2022.01.006 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Wesemann, Duane R.
Omicron’s message on vaccines: Boosting begets breadth
title Omicron’s message on vaccines: Boosting begets breadth
title_full Omicron’s message on vaccines: Boosting begets breadth
title_fullStr Omicron’s message on vaccines: Boosting begets breadth
title_full_unstemmed Omicron’s message on vaccines: Boosting begets breadth
title_short Omicron’s message on vaccines: Boosting begets breadth
title_sort omicron’s message on vaccines: boosting begets breadth
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758338/
https://www.ncbi.nlm.nih.gov/pubmed/35065712
http://dx.doi.org/10.1016/j.cell.2022.01.006
work_keys_str_mv AT wesemannduaner omicronsmessageonvaccinesboostingbegetsbreadth

Ejemplares similares