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Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated wh...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758471/ https://www.ncbi.nlm.nih.gov/pubmed/34272488 http://dx.doi.org/10.1038/s41380-021-01208-9 |
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author | Yang, Sujeong Gigout, Sylvain Molinaro, Angelo Naito-Matsui, Yuko Hilton, Sam Foscarin, Simona Nieuwenhuis, Bart Tan, Chin Lik Verhaagen, Joost Pizzorusso, Tommaso Saksida, Lisa M. Bussey, Timothy M. Kitagawa, Hiroshi Kwok, Jessica C. F. Fawcett, James W. |
author_facet | Yang, Sujeong Gigout, Sylvain Molinaro, Angelo Naito-Matsui, Yuko Hilton, Sam Foscarin, Simona Nieuwenhuis, Bart Tan, Chin Lik Verhaagen, Joost Pizzorusso, Tommaso Saksida, Lisa M. Bussey, Timothy M. Kitagawa, Hiroshi Kwok, Jessica C. F. Fawcett, James W. |
author_sort | Yang, Sujeong |
collection | PubMed |
description | Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment. |
format | Online Article Text |
id | pubmed-8758471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87584712022-01-17 Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing Yang, Sujeong Gigout, Sylvain Molinaro, Angelo Naito-Matsui, Yuko Hilton, Sam Foscarin, Simona Nieuwenhuis, Bart Tan, Chin Lik Verhaagen, Joost Pizzorusso, Tommaso Saksida, Lisa M. Bussey, Timothy M. Kitagawa, Hiroshi Kwok, Jessica C. F. Fawcett, James W. Mol Psychiatry Article Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment. Nature Publishing Group UK 2021-07-16 2021 /pmc/articles/PMC8758471/ /pubmed/34272488 http://dx.doi.org/10.1038/s41380-021-01208-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Sujeong Gigout, Sylvain Molinaro, Angelo Naito-Matsui, Yuko Hilton, Sam Foscarin, Simona Nieuwenhuis, Bart Tan, Chin Lik Verhaagen, Joost Pizzorusso, Tommaso Saksida, Lisa M. Bussey, Timothy M. Kitagawa, Hiroshi Kwok, Jessica C. F. Fawcett, James W. Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title | Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title_full | Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title_fullStr | Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title_full_unstemmed | Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title_short | Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
title_sort | chondroitin 6-sulphate is required for neuroplasticity and memory in ageing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758471/ https://www.ncbi.nlm.nih.gov/pubmed/34272488 http://dx.doi.org/10.1038/s41380-021-01208-9 |
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